{"id":"W4415948461","doi":"10.3389/fneur.2025.1523814","title":"Does C1 esterase inhibitor play a role in post COVID-19 neurological symptoms? A randomized, double-blind, placebo-controlled, crossover, proof-of-concept study","year":2025,"lang":"en","type":"article","venue":"Frontiers in Neurology","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Esterase; Pathogenesis; Clinical neurology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003695766,0.00206706,0.005757688,0.0005475396,0.0006823026,0.001237376,0.001605831,0.003712376,0.01042876],"category_scores_gemma":[0.002485204,0.001054947,0.002198844,0.0005216333,0.001694559,0.001693639,0.0004470707,0.003097666,0.001349429],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005772785,"about_ca_system_score_gemma":0.001728704,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004877753,"about_ca_topic_score_gemma":0.0009770957,"domain_scores_codex":[0.9989781,0.0004531845,0.00009642268,0.0001985837,0.0000986993,0.0001749781],"domain_scores_gemma":[0.9984685,0.0004243259,0.0003896889,0.0001440267,0.0001883794,0.0003850971],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9752811,0.01485309,0.0001361256,0.0009677497,0.0004210267,0.00002254962,0.00002645611,0.00006047727,0.002932692,0.00006239542,0.0003062754,0.004930069],"study_design_scores_gemma":[0.9135504,0.08497293,0.0004044619,0.00003095729,0.0002758433,0.00001167617,0.00001079091,0.00008487942,0.0002650301,0.00005850045,0.0003263959,0.000008099848],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.948445,0.01020987,0.002358471,0.001448075,0.00269165,0.03067012,0.001877696,0.0002632449,0.002035764],"genre_scores_gemma":[0.9379109,0.00684188,0.006781337,0.002485832,0.001909046,0.03754828,0.00115259,0.000044772,0.005325492],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01042876,"threshold_uncertainty_score":0.03488767,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01111580660310718,"score_gpt":0.2878900473536439,"score_spread":0.2767742407505367,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}