{"id":"W4415948522","doi":"10.1093/ismejo/wraf248","title":"Competitive fitness of <i>Staphylococcus aureus</i> against nasal commensals depends on biotin biosynthesis and acquisition","year":2025,"lang":"en","type":"article","venue":"The ISME Journal","topic":"Biotin and Related Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Innovation Cluster (Canada)","funders":"","keywords":"Auxotrophy; Biotin; Commensalism; Microbiome; Pathogen; Staphylococcus aureus; Human pathogen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003088186,0.0001260841,0.0001658992,0.00005838612,0.0002619587,0.00002398424,0.0001548132,0.0001363976,0.000008278514],"category_scores_gemma":[0.00003929487,0.00007887363,0.00008471556,0.00008679628,0.0002153162,0.000002192349,0.000105153,0.0002137475,0.000001332964],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001013318,"about_ca_system_score_gemma":0.00003276077,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003391774,"about_ca_topic_score_gemma":0.000006280408,"domain_scores_codex":[0.9992707,0.000135692,0.0002083764,0.0001316853,0.0001001211,0.0001534015],"domain_scores_gemma":[0.999526,0.00006439668,0.0001317656,0.0001505499,0.00009097355,0.00003626799],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002293602,0.0001237917,0.001423587,0.0000295245,0.0004952552,0.000005261354,0.0001833615,0.00004398681,0.9806949,0.001408037,0.00896411,0.006398756],"study_design_scores_gemma":[0.001027821,0.0003263297,0.01082707,0.0002591268,0.00009098632,0.00002072864,0.001015886,0.00002331108,0.9640088,0.0003039732,0.02192463,0.0001713512],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9828592,0.002757051,0.0001605053,0.005586356,0.0002778641,0.0001016157,0.00003562349,0.000006414307,0.008215378],"genre_scores_gemma":[0.9958335,0.002217544,0.00008346092,0.001447593,0.0001295397,0.000001451465,0.00000727251,0.000007814783,0.000271864],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01668618,"threshold_uncertainty_score":0.3216373,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005265912718123122,"score_gpt":0.239635161143386,"score_spread":0.2343692484252629,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}