{"id":"W4415949121","doi":"10.1039/d5pm00118h","title":"Spray-dried inhalable nano-embedded microparticles of isoniazid and pyridoxine hydrochloride for pulmonary tuberculosis","year":2025,"lang":"en","type":"article","venue":"RSC Pharmaceutics","topic":"Inhalation and Respiratory Drug Delivery","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Dr. Babasaheb Ambedkar Research and Training Institute; National Research Foundation; Arthritis National Research Foundation","keywords":"Isoniazid; Pulmonary tuberculosis; Pyridoxine; Tuberculosis; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002656878,0.0001737673,0.0003542097,0.0001866369,0.0001138683,0.00001510704,0.00007437712,0.000109609,0.00006511225],"category_scores_gemma":[0.00008975101,0.0001599647,0.0001076406,0.0003105653,0.0001455286,0.00008398922,0.00006517455,0.000150375,0.00001139316],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004980927,"about_ca_system_score_gemma":0.0001343684,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005045818,"about_ca_topic_score_gemma":0.000001390634,"domain_scores_codex":[0.9988401,0.00003649091,0.0004267164,0.0002570855,0.0001608869,0.0002787471],"domain_scores_gemma":[0.9991953,0.0001340841,0.00009925917,0.0002224089,0.000212838,0.0001360438],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006434766,0.0003713698,0.004922195,0.0007152735,0.0001923138,0.00001515713,0.0001707073,0.00004807426,0.9851664,0.0002895171,0.002209985,0.005255545],"study_design_scores_gemma":[0.002462131,0.00008440162,0.0004081046,0.0001378403,0.0004221505,0.00002786689,0.0001519246,0.01136433,0.9349774,0.00006371034,0.04976058,0.0001395304],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916251,0.002502864,0.0002601668,0.001635787,0.0003040138,0.0006738707,0.00004182377,0.00006522622,0.002891139],"genre_scores_gemma":[0.9940115,0.0004272256,0.0009043789,0.002489451,0.000106007,0.00003297634,0.00002124458,0.00002403086,0.001983159],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05018895,"threshold_uncertainty_score":0.652317,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02290122154114313,"score_gpt":0.3338247298101325,"score_spread":0.3109235082689893,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}