{"id":"W4415950660","doi":"10.1098/rstb.2024.0402","title":"Valganciclovir for cytomegalovirus viraemia in advanced HIV disease: a phase 2b randomized placebo-controlled trial of valganciclovir for cytomegalovirus viraemia in adults and adolescents with advanced HIV disease","year":2025,"lang":"en","type":"review","venue":"Philosophical Transactions of the Royal Society B Biological Sciences","topic":"Cytomegalovirus and herpesvirus research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"National Institute of Neurological Disorders and Stroke; Medical Research Council; National Institutes of Health","keywords":"Valganciclovir; Viral load; Cytomegalovirus; Ganciclovir; Adverse effect; Context (archaeology); Hazard ratio; Clinical endpoint","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0024244,0.002332399,0.00298825,0.0005994304,0.0005790129,0.001297035,0.001303894,0.003014244,0.008027889],"category_scores_gemma":[0.002212884,0.00108717,0.001780005,0.0003753833,0.001359761,0.001421043,0.0005347278,0.003700239,0.001145599],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006125044,"about_ca_system_score_gemma":0.001404756,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00113342,"about_ca_topic_score_gemma":0.002620925,"domain_scores_codex":[0.999141,0.0004919831,0.00004903956,0.0001249144,0.00005294664,0.0001400589],"domain_scores_gemma":[0.9990367,0.0002656131,0.0001744434,0.00006027337,0.00006999399,0.0003929416],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9733879,0.01279068,0.0002811419,0.0006269178,0.0004051251,0.00003262238,0.00005953729,0.000163686,0.002330666,0.0001014577,0.0006523686,0.009167882],"study_design_scores_gemma":[0.9628114,0.03585077,0.0005368036,0.00002111505,0.0000977907,0.00001102277,0.00001205212,0.00009934157,0.0001501907,0.00005244368,0.0003509466,0.000005971521],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9645136,0.005367077,0.0009364647,0.001226714,0.001221313,0.02140029,0.00207638,0.0002353891,0.003022807],"genre_scores_gemma":[0.9522181,0.00519789,0.003912447,0.002217871,0.0007885281,0.02786601,0.001746645,0.00004636413,0.006006056],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008027889,"threshold_uncertainty_score":0.02685595,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03651864825613973,"score_gpt":0.3567802058851347,"score_spread":0.320261557628995,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}