{"id":"W4415952016","doi":"10.3324/haematol.2025.288838","title":"CD19 directed CAR T therapy for intravascular large B-cell lymphoma","year":2025,"lang":"en","type":"article","venue":"Haematologica","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Leukemia & Lymphoma Society of Canada; BC Cancer Agency","funders":"Cancer Moonshot; National Institute of Allergy and Infectious Diseases; National Cancer Institute; Office of Naval Research; National Heart, Lung, and Blood Institute; Astellas Pharma US; Health Resources and Services Administration; National Institutes of Health; Gilead Sciences; Actinium Pharmaceuticals; Adaptive Biotechnologies; Moonshot Research and Development Program; AstraZeneca; Gateway for Cancer Research; Astellas Pharma; Alexion Pharmaceuticals; Amgen","keywords":"Lymphoma; CD19; Chimeric antigen receptor; Aggressive lymphoma; CAR T-cell therapy; Antibody therapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0004300258,0.0002215407,0.0006350143,0.0001850926,0.0001591634,0.00003148679,0.0002258361,0.0002381786,0.001531912],"category_scores_gemma":[0.000194964,0.0001638489,0.0003140663,0.0004451441,0.00009638,0.00003030966,0.00006826402,0.0001444082,0.00007172512],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009140772,"about_ca_system_score_gemma":0.0001965441,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000332099,"about_ca_topic_score_gemma":0.00001369832,"domain_scores_codex":[0.998284,0.0001156498,0.0002957998,0.000452754,0.0002752635,0.0005765613],"domain_scores_gemma":[0.9987361,0.0002431175,0.0000523764,0.0006264768,0.0002162527,0.0001257079],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0134387,0.01325941,0.0287025,0.002455554,0.002616761,0.001558068,0.001752026,0.000003404259,0.4646348,0.02036333,0.1798027,0.2714127],"study_design_scores_gemma":[0.02167798,0.0007436206,0.006043782,0.0001129375,0.0001002097,0.00009346741,0.0003244155,0.0007352885,0.2013049,0.001263642,0.7673032,0.0002965358],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9533573,0.005662326,0.001375341,0.002250306,0.0002607067,0.002510656,0.00002520225,0.000525264,0.03403283],"genre_scores_gemma":[0.9731637,0.001347992,0.001491637,0.002101981,0.00008629294,0.0004478852,0.0000741755,0.00003936631,0.02124698],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5875005,"threshold_uncertainty_score":0.9993808,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0238263675914537,"score_gpt":0.3159687436674928,"score_spread":0.2921423760760391,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}