{"id":"W4415952016","doi":"10.3324/haematol.2025.288838","title":"CD19 directed CAR T therapy for intravascular large B-cell lymphoma","year":2025,"lang":"en","type":"article","venue":"Haematologica","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Leukemia & Lymphoma Society of Canada; BC Cancer Agency","funders":"Cancer Moonshot; National Institute of Allergy and Infectious Diseases; National Cancer Institute; Office of Naval Research; National Heart, Lung, and Blood Institute; Astellas Pharma US; Health Resources and Services Administration; National Institutes of Health; Gilead Sciences; Actinium Pharmaceuticals; Adaptive Biotechnologies; Moonshot Research and Development Program; AstraZeneca; Gateway for Cancer Research; Astellas Pharma; Alexion Pharmaceuticals; Amgen","keywords":"Lymphoma; CD19; Chimeric antigen receptor; Aggressive lymphoma; CAR T-cell therapy; Antibody therapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004931218,0.0002420204,0.0004304014,0.0002729571,0.0002791127,0.0007172139,0.0007704165,0.001214934,0.03400837],"category_scores_gemma":[0.0006789484,0.0001279402,0.0004220011,0.0003578772,0.0002360987,0.0007138841,0.0002220904,0.001058987,0.005534154],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005688152,"about_ca_system_score_gemma":0.0006419191,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005537537,"about_ca_topic_score_gemma":0.001636495,"domain_scores_codex":[0.9997301,0.00009951393,0.00002359701,0.00002677421,0.0000531814,0.00006695374],"domain_scores_gemma":[0.9997143,0.0001185945,0.00003162241,0.00003436386,0.00002803151,0.00007305978],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.02137678,0.003390434,0.002253462,0.003923689,0.0006957893,0.002123344,0.0001133504,0.001093144,0.03784929,0.006236964,0.1757308,0.745213],"study_design_scores_gemma":[0.008517837,0.01492638,0.005960589,0.0009649885,0.0006737328,0.003341764,0.0001087025,0.0008285246,0.02588558,0.002275697,0.9364857,0.00003046386],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.2387571,0.3423349,0.01003077,0.03772816,0.0117267,0.002706737,0.02192842,0.001111947,0.3336752],"genre_scores_gemma":[0.7435657,0.1123743,0.007652034,0.01139852,0.002234355,0.001710431,0.01489589,0.0001472212,0.1060215],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.03400837,"threshold_uncertainty_score":0.1137693,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0238263675914537,"score_gpt":0.3159687436674928,"score_spread":0.2921423760760391,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}