{"id":"W4415952024","doi":"10.3324/haematol.2025.288743","title":"&lt;i&gt;IDH2&lt;/i&gt; mutation is associated with favorable outcome among older adults with newly diagnosed acute myeloid leukemia treated with hypomethylating agent-based therapy","year":2025,"lang":"en","type":"article","venue":"Haematologica","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Genentech; Sun Pharma; MorphoSys; Astellas Pharma; Sierra Oncology; Incyte; Swedish Orphan Biovitrum; Daiichi Sankyo Europe; Oregon Health and Science University; Gilead Sciences; Amgen; Pfizer; Syndax Pharmaceuticals; Foghorn Therapeutics","keywords":"NPM1; Myeloid leukemia; Isocitrate dehydrogenase; IDH1; Hypomethylating agent; Azacitidine; Retrospective cohort study; Cohort; Mutation","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006542176,0.0009275861,0.00180471,0.0006243683,0.0005652917,0.0001739995,0.0004805527,0.0006028512,0.0003560106],"category_scores_gemma":[0.000570619,0.0005644175,0.0002169602,0.002982167,0.0006326556,0.0003369299,0.00008864583,0.0009354111,0.00006194274],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00152899,"about_ca_system_score_gemma":0.001452784,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003124087,"about_ca_topic_score_gemma":0.0004804117,"domain_scores_codex":[0.9945855,0.0004442955,0.0009251351,0.001355963,0.001313766,0.001375373],"domain_scores_gemma":[0.9956805,0.0011819,0.0006827873,0.001063595,0.000958444,0.0004327555],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0199433,0.00184113,0.9070859,0.0007887741,0.006136804,0.02403949,0.003229331,0.001335122,0.01235446,0.0003128353,0.01035049,0.01258238],"study_design_scores_gemma":[0.09020603,0.007830335,0.8140723,0.005418674,0.001873222,0.0006296152,0.001211776,0.01871718,0.05669926,0.00005123524,0.001250763,0.002039629],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9871018,0.0004192107,0.002311165,0.001700643,0.00004278862,0.003453056,0.00006134954,0.0007793871,0.004130614],"genre_scores_gemma":[0.9865444,0.0001354,0.004935741,0.001975536,0.00003230266,0.0007848176,0.0005522972,0.0001503317,0.004889173],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0930136,"threshold_uncertainty_score":0.9996808,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01789843076102343,"score_gpt":0.274959400748029,"score_spread":0.2570609699870056,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}