{"id":"W4415952024","doi":"10.3324/haematol.2025.288743","title":"&lt;i&gt;IDH2&lt;/i&gt; mutation is associated with favorable outcome among older adults with newly diagnosed acute myeloid leukemia treated with hypomethylating agent-based therapy","year":2025,"lang":"en","type":"article","venue":"Haematologica","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Genentech; Sun Pharma; MorphoSys; Astellas Pharma; Sierra Oncology; Incyte; Swedish Orphan Biovitrum; Daiichi Sankyo Europe; Oregon Health and Science University; Gilead Sciences; Amgen; Pfizer; Syndax Pharmaceuticals; Foghorn Therapeutics","keywords":"NPM1; Myeloid leukemia; Isocitrate dehydrogenase; IDH1; Hypomethylating agent; Azacitidine; Retrospective cohort study; Cohort; Mutation","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002857701,0.0001138497,0.0003159784,0.0002905678,0.0002149771,0.0003505385,0.0001191936,0.0001838264,0.0008256603],"category_scores_gemma":[0.0009064155,0.00010854,0.0002439087,0.0004101259,0.00015749,0.0002460249,0.0002076988,0.0002842132,0.0001137776],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001645174,"about_ca_system_score_gemma":0.0001855898,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001001744,"about_ca_topic_score_gemma":0.001725745,"domain_scores_codex":[0.9998394,0.0000271914,0.00002338789,0.00004656936,0.00003405865,0.00002929344],"domain_scores_gemma":[0.9992704,0.00008393812,0.0004349968,0.0000363013,0.00003720961,0.0001372298],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003935973,0.00002310631,0.9966132,0.000007418934,0.00002687315,0.0001125772,0.00001927968,0.00004089163,0.0006646567,0.00001127457,0.00006931241,0.002017783],"study_design_scores_gemma":[0.00001881085,0.0001800874,0.9985573,0.000003988967,0.00003973547,0.000577005,0.00004479934,0.0001415537,0.0001294228,0.00001693562,0.0002879205,0.000002474185],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994627,0.0002225765,0.00002854578,0.00001707868,0.000003909726,0.000003413091,0.0001028083,0.000001110727,0.00015801],"genre_scores_gemma":[0.9996111,0.00009088194,0.00002239494,0.00001945263,0.00001102705,0.000003150436,0.0001756722,7.127122e-7,0.00006567585],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001001744,"threshold_uncertainty_score":0.002762139,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01789843076102343,"score_gpt":0.274959400748029,"score_spread":0.2570609699870056,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}