{"id":"W4415958291","doi":"10.1038/s41467-025-64888-9","title":"Click-linking: a cell-compatible protein crosslinking method based on click chemistry","year":2025,"lang":"en","type":"article","venue":"Nature Communications","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Interactome; Click chemistry; Mass spectrometry; Cycloaddition; Proteome; Subtractive color; Sampling (signal processing)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005631257,0.001062541,0.0003748144,0.0005565492,0.0003273842,0.00053191,0.0006947314,0.0008903102,0.001775644],"category_scores_gemma":[0.0003702387,0.0002970163,0.0004442857,0.0003784772,0.0004232888,0.000676691,0.0004547173,0.001060965,0.0009606622],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003142186,"about_ca_system_score_gemma":0.0003881016,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002761721,"about_ca_topic_score_gemma":0.0004162004,"domain_scores_codex":[0.9996351,0.00004498953,0.00003166931,0.0001016152,0.0001474492,0.00003920941],"domain_scores_gemma":[0.9997222,0.00008415485,0.00007496289,0.00003784917,0.00003426393,0.0000464717],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004040002,0.00003125374,0.0001050672,0.00008772188,0.00001040787,0.00008444759,0.00001325067,0.00008514702,0.9945199,0.0004638149,0.0003202154,0.00423833],"study_design_scores_gemma":[0.000007964595,0.000114524,0.0002879188,0.000002919632,0.00001064516,0.0002894567,0.000002909853,0.0006379506,0.9945039,0.00007948149,0.00405184,0.00001052723],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.5026652,0.01143868,0.4670163,0.001095331,0.0006658849,0.0006985848,0.001802183,0.004880446,0.00973744],"genre_scores_gemma":[0.7913171,0.009828812,0.1800022,0.0007823656,0.0002257852,0.0005039267,0.002828033,0.0004192831,0.01409243],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.001775644,"threshold_uncertainty_score":0.005940139,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0199812357779089,"score_gpt":0.3486491473766947,"score_spread":0.3286679115987858,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}