{"id":"W4415958703","doi":"10.1186/s13059-025-03821-1","title":"ERV3-MLT1 provides cis-regulatory elements for human placental functioning and are commonly dysregulated in human-specific preeclampsia","year":2025,"lang":"en","type":"article","venue":"Genome biology","topic":"Pregnancy and preeclampsia studies","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"National University of Sciences and Technology; China Scholarship Council; Deutsche Forschungsgemeinschaft","keywords":"Human genetics; Preeclampsia; Gene; Placenta Diseases; Genome Biology; Human genome; Placenta; Human physiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002903221,0.0002336242,0.0005103783,0.0002513007,0.0003836748,0.00001670242,0.0001169161,0.0002157379,0.0000408099],"category_scores_gemma":[0.0000235379,0.0002172739,0.00007694124,0.0001702085,0.0002657117,0.00005184159,0.0001584706,0.0002002306,0.000003018115],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001421037,"about_ca_system_score_gemma":0.00003972147,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002483429,"about_ca_topic_score_gemma":0.0003290893,"domain_scores_codex":[0.998477,0.00008899982,0.0004659467,0.000490313,0.00006596947,0.000411805],"domain_scores_gemma":[0.9993504,0.00008486986,0.0001413816,0.0003081924,0.00005850974,0.00005669516],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006150405,0.0001904681,0.8622958,0.0004294496,0.0003560944,0.000009963301,0.0005549883,0.000004489325,0.1201041,0.009525456,0.0009202657,0.004993862],"study_design_scores_gemma":[0.004142402,0.0005266341,0.9554901,0.0003288301,0.00006929488,0.00001027421,0.0004520696,0.00001785884,0.0008128139,0.004051926,0.03388569,0.0002121088],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9812514,0.01460194,0.0001975336,0.0004160762,0.000219915,0.001308502,0.00005871987,0.00009105763,0.001854917],"genre_scores_gemma":[0.9973097,0.0001136942,0.0003156347,0.0002453934,0.0001079701,0.0002253667,0.0002893756,0.0000192135,0.001373584],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1192913,"threshold_uncertainty_score":0.8860173,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02880748427768083,"score_gpt":0.3001868323831471,"score_spread":0.2713793481054663,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}