{"id":"W4415962643","doi":"10.1080/21678421.2025.2582830","title":"ALSUntangled #81: Pyridostigmine (mestinon <sup>®</sup> )","year":2025,"lang":"en","type":"review","venue":"Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Hope Foundation; ALS Hope Foundation","keywords":"Pyridostigmine; Pyridostigmine Bromide; Neuromuscular junction; Neuromuscular transmission; Myasthenia gravis; Cholinergic; Acetylcholine","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003842397,0.0007457002,0.0008604435,0.001891182,0.0002514525,0.0008322523,0.0007011697,0.0009796143,0.02378002],"category_scores_gemma":[0.0004492617,0.0001644374,0.0006359178,0.00125222,0.0002324786,0.0006945381,0.0005403087,0.001238295,0.0112175],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004511728,"about_ca_system_score_gemma":0.0008382781,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001592876,"about_ca_topic_score_gemma":0.003681696,"domain_scores_codex":[0.9998828,0.00001824714,0.00001730676,0.00002187741,0.00004440745,0.00001525653],"domain_scores_gemma":[0.9998591,0.00004551395,0.00003181352,0.000005985946,0.00003195168,0.00002559391],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001848686,0.00005736299,0.00007348847,0.01417948,0.0001062984,0.0001148461,0.0000298821,0.00008566033,0.002923803,0.001554736,0.04791727,0.9327723],"study_design_scores_gemma":[0.00009634954,0.0001477271,0.0007543204,0.003740252,0.000183992,0.0007819512,0.00002228973,0.00003621467,0.001042584,0.000527885,0.9926564,0.000009947861],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004966588,0.9899734,0.0002069157,0.0003903813,0.0003451341,0.00003281096,0.0002094319,0.00007754184,0.00826768],"genre_scores_gemma":[0.003843164,0.9835147,0.0004886158,0.0005892378,0.0001953303,0.00003909897,0.0006431345,0.00001577551,0.0106711],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.02378002,"threshold_uncertainty_score":0.07955211,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06564507204752004,"score_gpt":0.3216435710068726,"score_spread":0.2559984989593526,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}