{"id":"W4415962648","doi":"10.1158/0008-5472.can-25-3502","title":"Enozertinib Is a Selective, Brain-Penetrant EGFR Inhibitor for Treating Non–Small Cell Lung Cancers with EGFR Exon 20 and Atypical Mutations","year":2025,"lang":"en","type":"article","venue":"Cancer Research","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Paraza Pharma (Canada)","funders":"","keywords":"Kinome; Exon; EGFR inhibitors; Lung; Epidermal growth factor receptor; Erlotinib; Cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001188886,0.0003101267,0.0002611126,0.0002411689,0.0001435161,0.0002941865,0.0002197637,0.0002445248,0.0007929655],"category_scores_gemma":[0.00007405116,0.00006191868,0.0002146741,0.0001828627,0.0001511558,0.0002200832,0.0001767709,0.0004952524,0.0003877599],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003663111,"about_ca_system_score_gemma":0.0002746015,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005428929,"about_ca_topic_score_gemma":0.002328164,"domain_scores_codex":[0.9999295,0.00001022504,0.000006874502,0.00001340955,0.0000223251,0.00001764221],"domain_scores_gemma":[0.9999739,0.000003154373,0.000009146615,0.000001536568,0.00000471461,0.000007417929],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002347502,0.0007754871,0.003282003,0.001186506,0.0001447819,0.001627076,0.00006733829,0.001642353,0.6347622,0.001804554,0.003844364,0.3485159],"study_design_scores_gemma":[0.001891447,0.01529402,0.02468429,0.0002408957,0.0004440652,0.02581984,0.0001424017,0.006423821,0.7191245,0.0008901351,0.2049392,0.0001053657],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8357874,0.1272296,0.01128612,0.001734366,0.0003074584,0.0004055114,0.001233844,0.0006415859,0.0213741],"genre_scores_gemma":[0.9529718,0.03571679,0.002996826,0.0003288036,0.00005272273,0.00005916909,0.001146477,0.00001282162,0.006714588],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007929655,"threshold_uncertainty_score":0.002657831,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03079200009346279,"score_gpt":0.4108915992425694,"score_spread":0.3800995991491066,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}