{"id":"W4415964571","doi":"10.1039/d5gc04619j","title":"Solvent-less environmentally benign amino ester, amide, and peptide synthesis enabled by resonant acoustic mixing","year":2025,"lang":"en","type":"article","venue":"Green Chemistry","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Terry Fox Research Institute; Université du Québec à Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Fonds de recherche du Québec – Nature et technologies; Canadian Institutes of Health Research; Université de Montréal; Centre in Green Chemistry and Catalysis","keywords":"Mixing (physics); Peptide; Peptide bond; Amide; Peptide synthesis; On demand","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002614073,0.000375203,0.0002129001,0.0001556512,0.0001363947,0.0002596541,0.0002360419,0.0002840431,0.001684043],"category_scores_gemma":[0.0002620049,0.0001880506,0.0001768004,0.0001335349,0.0002738955,0.0004720721,0.0004545278,0.0005214454,0.001076156],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001479045,"about_ca_system_score_gemma":0.0002034446,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001394735,"about_ca_topic_score_gemma":0.0003703312,"domain_scores_codex":[0.9998454,0.00002112698,0.000009509717,0.00004233587,0.00005686313,0.00002472814],"domain_scores_gemma":[0.9999132,0.00002045268,0.00002880689,0.0000108542,0.00001225703,0.00001433064],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002292146,0.000005133165,0.00001914442,0.00003821871,0.000001306851,0.00002795528,0.00001057026,0.00008818461,0.9963053,0.0006187259,0.00004549991,0.002817017],"study_design_scores_gemma":[0.000008805548,0.00007285962,0.00012121,0.000003579486,0.000002846175,0.00009160964,0.000005926985,0.0009419802,0.9950918,0.0001667117,0.00348622,0.000006437395],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.8106012,0.006634762,0.161064,0.0005214756,0.0002519662,0.0001613974,0.0003791478,0.001131959,0.01925405],"genre_scores_gemma":[0.9129223,0.003467643,0.07605115,0.0002081386,0.00007635675,0.00008187191,0.0002418708,0.0001442347,0.00680648],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.001684043,"threshold_uncertainty_score":0.005633652,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004685605592573572,"score_gpt":0.1998931407416128,"score_spread":0.1952075351490392,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}