{"id":"W4415965478","doi":"10.1186/s12950-025-00476-4","title":"Lack of phospho-eIF4E worsens experimental colitis by inhibiting Treg suppressive activity","year":2025,"lang":"en","type":"article","venue":"Journal of Inflammation","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University; Jewish General Hospital","funders":"Vetenskapsrådet; Canadian Institutes of Health Research; Merck Canada; Cancer Research Society; McGill University; Pfizer","keywords":"Colitis; Immunopharmacology; Ulcerative colitis; Human physiology; Inflammatory bowel disease; Inflammation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002126027,0.00009483938,0.000170736,0.00005861647,0.00004025905,0.00001802133,0.0001041691,0.0001096437,0.00002730917],"category_scores_gemma":[0.0001386709,0.00009299731,0.0001018047,0.00008022831,0.00005130985,0.00001682766,0.00004325386,0.0001074412,8.415863e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007112869,"about_ca_system_score_gemma":0.0001327298,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001512068,"about_ca_topic_score_gemma":0.000006310874,"domain_scores_codex":[0.9991812,0.00006342506,0.0003707231,0.0001037517,0.0001647077,0.0001161536],"domain_scores_gemma":[0.9990429,0.00002732284,0.0005690528,0.00009916235,0.0002245486,0.00003705272],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002917146,0.00003995399,0.0006723405,0.00002434403,0.000068876,0.000003191036,0.0001205981,0.0001366392,0.9908137,0.00003816033,0.004907072,0.002883387],"study_design_scores_gemma":[0.0007448868,0.0001905956,0.001066262,0.0001408754,0.00001972177,0.0000119583,0.0001821189,0.00007528415,0.9950802,0.00004556336,0.00236609,0.00007648303],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966971,0.0007442973,0.000941331,0.0001988266,0.0002385393,0.00008347106,0.00001534793,0.000002957371,0.001078073],"genre_scores_gemma":[0.99909,0.00005365818,0.0002684036,0.00004551024,0.0002310875,0.000004036584,0.00001230074,0.000008250535,0.0002868077],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004266437,"threshold_uncertainty_score":0.379232,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01192161914388941,"score_gpt":0.3037727917339715,"score_spread":0.2918511725900821,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}