{"id":"W4415969023","doi":"10.2139/ssrn.5691563","title":"Structure-based discovery of sulfamoyl-ethyl-4-oxo-3,4-dihydro-7H-pyrrolo[2,3-d]pyrimidine amides and sulfonamides as potent B-Cell Lymphoma 6 (BCL6)-BTB inhibitors","year":2025,"lang":"","type":"preprint","venue":"SSRN Electronic Journal","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ontario Institute for Cancer Research","funders":"","keywords":"Transcription factor; Drug discovery; Lymphoma; BCL6; Bromodomain; Transcription (linguistics); Virtual screening; Drug; Sulfonamide","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":["metaepi_narrow","research_integrity"],"category_scores_codex":[0.001726216,0.001392178,0.001392894,0.0006509659,0.0006446016,0.0003583422,0.0008097395,0.001604107,0.00003272773],"category_scores_gemma":[0.0002755952,0.001287117,0.001023114,0.00041877,0.0007537452,0.00007475202,0.0007993129,0.00262928,0.000003678997],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001340201,"about_ca_system_score_gemma":0.01262241,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004841438,"about_ca_topic_score_gemma":0.000935711,"domain_scores_codex":[0.9918548,0.0006060281,0.002021142,0.001617509,0.0008772401,0.003023234],"domain_scores_gemma":[0.9958144,0.0001303467,0.002004442,0.001050148,0.0006497628,0.0003508755],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00769389,0.00191431,0.004181529,0.001485819,0.003278311,0.00003358226,0.0002691711,0.02125646,0.8985671,0.005990668,0.0003730006,0.05495609],"study_design_scores_gemma":[0.01004586,0.003270909,0.002222919,0.0008714579,0.001038408,0.0006173122,0.001204459,0.001516552,0.9344903,0.0385482,0.004350631,0.001823004],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9546729,0.03492037,0.005625704,0.0008968787,0.002288299,0.0008183965,0.0002861144,0.00002798816,0.0004633737],"genre_scores_gemma":[0.9499127,0.04190471,0.0001527545,0.0003362245,0.0009412238,0.00002427504,0.0006863788,0.000102986,0.005938804],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05313308,"threshold_uncertainty_score":0.9998829,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003597610411223458,"score_gpt":0.2136761900506826,"score_spread":0.2100785796394592,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}