{"id":"W4415970830","doi":"10.1126/science.adv4257","title":"A non-enzymatic role of Nudix hydrolase 5 in repressing purine de novo synthesis","year":2025,"lang":"en","type":"article","venue":"Science","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Discovery Centre","funders":"Austrian Science Fund; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; European Research Council; Wellcome Trust; Wellcome","keywords":"De novo synthesis; Purine metabolism; Purine; Glutamine amidotransferase; Enzyme; Purine analogue; Hydrolase; Adenine phosphoribosyltransferase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001602566,0.0002676749,0.0002147051,0.0001349225,0.0001866688,0.0003600411,0.000233284,0.0003817173,0.0008243145],"category_scores_gemma":[0.0001765873,0.000121617,0.0001977363,0.00007298868,0.0002695874,0.0003096859,0.0001923496,0.0003039704,0.0002089126],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003198128,"about_ca_system_score_gemma":0.0001824127,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003569749,"about_ca_topic_score_gemma":0.0006549285,"domain_scores_codex":[0.9998884,0.00001617551,0.00001348098,0.00003747604,0.00002607471,0.00001840229],"domain_scores_gemma":[0.9998769,0.00002732304,0.00003429817,0.00002025592,0.000009462133,0.00003184711],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003788989,0.000004479198,0.0003189622,0.00002791586,0.000003669703,0.00008219306,0.000007834069,0.00004894347,0.9981365,0.0002579527,0.0000120437,0.001061552],"study_design_scores_gemma":[0.00000606334,0.00009852089,0.0051724,0.000005828833,0.000007541841,0.000375717,0.00001917898,0.0007766906,0.9913712,0.0001001544,0.002063293,0.000003486914],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9829414,0.006845434,0.007806052,0.0001729497,0.00004372671,0.00001584497,0.0002033513,0.0001088314,0.001862347],"genre_scores_gemma":[0.9955758,0.0005230141,0.00236799,0.00003536433,0.000004400924,0.000005399608,0.0001685383,0.000005740752,0.001313793],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008243145,"threshold_uncertainty_score":0.002757549,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003790634215415347,"score_gpt":0.2816122219108722,"score_spread":0.2778215876954568,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}