{"id":"W4415971716","doi":"10.1101/2025.11.04.25339335","title":"Elenagen, a p62/SQSTM1-encoding plasmid, improves overall survival in platinum-resistant ovarian cancer patients: a phase II trial","year":2025,"lang":"","type":"preprint","venue":"medRxiv","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Gemcitabine; Clinical endpoint; Ovarian cancer; Overall survival; Survival analysis; Phases of clinical research; Clinical trial; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008871171,0.0007037139,0.001274127,0.0002904758,0.0002241796,0.0005687309,0.0004626166,0.001098015,0.002635495],"category_scores_gemma":[0.000645637,0.0002576156,0.0008094604,0.00030522,0.0006155314,0.0005716093,0.0002428329,0.001665275,0.0002989421],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003551898,"about_ca_system_score_gemma":0.0005078969,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003241526,"about_ca_topic_score_gemma":0.0007869262,"domain_scores_codex":[0.9997975,0.00009650628,0.00001480123,0.00003991563,0.00001924593,0.00003212206],"domain_scores_gemma":[0.9996118,0.00009962208,0.00008782306,0.00002840997,0.0000223018,0.0001500462],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8604901,0.03188621,0.002623549,0.001124986,0.001247647,0.0001271547,0.0001243296,0.001533937,0.02572485,0.000184487,0.001745724,0.07318691],"study_design_scores_gemma":[0.7659626,0.2254805,0.004074921,0.00003935083,0.0004809308,0.00006886687,0.00002626125,0.0008412945,0.001943918,0.0001056319,0.000960778,0.00001489069],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941051,0.002900056,0.0003265531,0.0003114143,0.00009755998,0.001046898,0.0003260841,0.00005734955,0.0008289175],"genre_scores_gemma":[0.9927098,0.002188857,0.0008270805,0.0005210715,0.0001386064,0.001408766,0.0006315236,0.00001089253,0.001563385],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002635495,"threshold_uncertainty_score":0.008816659,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02569926199712075,"score_gpt":0.3234022214232914,"score_spread":0.2977029594261706,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}