{"id":"W4415971790","doi":"10.1101/2025.11.04.25339477","title":"Plasma proteome signatures are predictive of mortality in sickle cell disease","year":2025,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Hemoglobinopathies and Related Disorders","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Canadian Institutes of Health Research; McGill University","keywords":"Proteome; Disease; Hazard ratio; Mortality rate; Blood proteins; Proportional hazards model; Acute chest syndrome; Hemoglobin; White blood cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007345207,0.0003487728,0.0003997901,0.0007471748,0.0002754608,0.0006553811,0.0001541326,0.0003882831,0.0009328884],"category_scores_gemma":[0.001713051,0.0001117903,0.0004238765,0.000696595,0.0001408822,0.000269399,0.0003995174,0.0005057522,0.0002405371],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001519451,"about_ca_system_score_gemma":0.0001233769,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000623227,"about_ca_topic_score_gemma":0.0005600551,"domain_scores_codex":[0.9996477,0.00009486866,0.00004240669,0.00009953591,0.00006916258,0.00004629847],"domain_scores_gemma":[0.9989445,0.0002727004,0.0004465453,0.00005944298,0.0001652503,0.0001116001],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004781981,0.00003620887,0.9884906,0.00004608342,0.0001810777,0.00009709654,0.00004149104,0.0004351121,0.005622355,0.00003954838,0.0005006341,0.004031484],"study_design_scores_gemma":[0.00001418133,0.0001096422,0.9913504,0.00002008266,0.0001194257,0.0004219513,0.00008508281,0.004635225,0.002351249,0.0002129641,0.000670438,0.000009409247],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967926,0.0009924903,0.0006354885,0.00007834852,0.00001895161,0.00000508214,0.001221915,0.00001804757,0.0002371536],"genre_scores_gemma":[0.9981029,0.0001775483,0.0004818735,0.00003850279,0.00002059583,0.000005417663,0.001067782,0.000002720848,0.0001026589],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009328884,"threshold_uncertainty_score":0.003884554,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01212872574806477,"score_gpt":0.2630613321849252,"score_spread":0.2509326064368604,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}