{"id":"W4415973831","doi":"10.1016/j.bneo.2025.100182","title":"Single-cell proteogenomic analysis of clonal evolution in PDX models of AML treated with IDH inhibitors","year":2025,"lang":"en","type":"article","venue":"Blood Neoplasia","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"Servier","keywords":"Somatic evolution in cancer; Myeloid leukemia; Isocitrate dehydrogenase; Drug resistance; Leukemia; Myeloid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002335404,0.0001773592,0.0006734278,0.001547663,0.00002425894,0.000005815244,0.0001304735,0.000156933,0.00002944926],"category_scores_gemma":[0.00004824384,0.0001479585,0.0001533792,0.003105151,0.0001402911,0.00007579035,0.00005979502,0.0002502961,0.000002623041],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003604759,"about_ca_system_score_gemma":0.0007222385,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001000183,"about_ca_topic_score_gemma":0.0003679835,"domain_scores_codex":[0.9983712,0.00008704119,0.0005229262,0.0003427832,0.0003832159,0.0002928564],"domain_scores_gemma":[0.9990467,0.00009080127,0.0001716088,0.0003927289,0.0002166161,0.00008151359],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002089954,0.001712367,0.4003433,0.0004063173,0.001964826,0.00007501919,0.000335455,0.005174606,0.586934,0.0002928721,0.0001377848,0.0005334452],"study_design_scores_gemma":[0.01206513,0.001602794,0.1478124,0.0005134519,0.005419394,0.00002669856,0.0003726919,0.03696289,0.7948001,0.0001450978,0.00003257957,0.0002467482],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940091,0.0002877041,0.0004336801,0.0001265902,0.00001128011,0.0007961327,0.00003173517,0.00002538788,0.004278328],"genre_scores_gemma":[0.9977689,0.00001591804,0.00133967,0.00001949071,0.0000182273,0.00004604647,0.00006408773,0.00001923268,0.0007083893],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2525309,"threshold_uncertainty_score":0.6033571,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01181312530648026,"score_gpt":0.2433775017054244,"score_spread":0.2315643763989442,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}