{"id":"W4415982994","doi":"10.3389/fmed.2025.1658588","title":"Pathways and challenges in the clinical translational of radiopharmaceuticals for pediatric investigations","year":2025,"lang":"en","type":"review","venue":"Frontiers in Medicine","topic":"Neuroblastoma Research and Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"National Institute of General Medical Sciences; National Institutes of Health; Delaware IDeA Network of Biomedical Research Excellence; National Institute of Biomedical Imaging and Bioengineering; Nemours Foundation","keywords":"Clinical trial; Food and drug administration; Positron emission tomography; Drug development; Translational research; Dosing; Clinical Practice; Drug","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.117252,0.0007635291,0.001154818,0.001599794,0.002388245,0.01259809,0.003651899,0.006930599,0.009502502],"category_scores_gemma":[0.1166296,0.0007221468,0.001015027,0.001358635,0.0148742,0.01103146,0.008984626,0.01601807,0.004142471],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.006045313,"about_ca_system_score_gemma":0.03632046,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002675835,"about_ca_topic_score_gemma":0.003057,"domain_scores_codex":[0.9380274,0.03735041,0.004726534,0.004993963,0.01217054,0.002731008],"domain_scores_gemma":[0.8245664,0.1103137,0.01227085,0.01305435,0.0289896,0.01080505],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000361995,0.000257393,0.004826793,0.002723938,0.00007905516,0.0009721629,0.002553904,0.001182344,0.002607613,0.4634265,0.1098514,0.4111569],"study_design_scores_gemma":[0.000130937,0.0004896474,0.002471544,0.005210157,0.00006254968,0.002276781,0.001785487,0.0009393648,0.003865839,0.2363082,0.7463577,0.0001017348],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"review","genre_scores_codex":[0.006540096,0.1934281,0.05807461,0.6909654,0.006127751,0.0004863651,0.0005682955,0.0004368461,0.04337264],"genre_scores_gemma":[0.2200188,0.3186197,0.1697329,0.2586559,0.01561817,0.003140352,0.001335106,0.0008226099,0.01205644],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.117252,"threshold_uncertainty_score":0.620095,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3653142586797544,"score_gpt":0.48412197605112,"score_spread":0.1188077173713656,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}