{"id":"W4415991532","doi":"10.21203/rs.3.rs-7846387/v1","title":"Kaiso (ZBTB33) engages with non-canonical binding motifs to regulate DNA damage responses in breast cancer cells","year":2025,"lang":"","type":"preprint","venue":"Research Square","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek; ZonMw","keywords":"DNA damage; Transcription factor; Chromatin immunoprecipitation; Chromatin; Gene expression; Regulation of gene expression; Breast cancer; G2-M DNA damage checkpoint; Cancer cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009471679,0.0002428267,0.0001547005,0.000195785,0.0002420687,0.0004503766,0.0002629792,0.0003230778,0.003642361],"category_scores_gemma":[0.0001275131,0.0002403867,0.0002509553,0.0002321067,0.0001931262,0.000234597,0.0003139809,0.0006849448,0.001474356],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005235104,"about_ca_system_score_gemma":0.0002715398,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001112296,"about_ca_topic_score_gemma":0.00212036,"domain_scores_codex":[0.9998541,0.00001272028,0.000004658698,0.0000319095,0.0000388047,0.00005772446],"domain_scores_gemma":[0.9999402,0.000006346214,0.00001994769,0.000005939323,0.000005908004,0.00002172129],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001484484,0.00001612949,0.0003836249,0.00003042914,0.000005648576,0.000039121,0.000009958465,0.00006859222,0.9981872,0.0002198953,0.0001190989,0.0007716891],"study_design_scores_gemma":[0.00003465029,0.00009031017,0.01302512,0.000007402492,0.00001654335,0.0003277464,0.00007846523,0.001916849,0.9800442,0.0001744013,0.004274549,0.000009586161],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992593,0.001815391,0.002388613,0.000234581,0.00003840932,0.00001544739,0.000427175,0.0001335245,0.002353794],"genre_scores_gemma":[0.9955971,0.0004361314,0.0005233504,0.00005872145,0.000003497906,0.00001088123,0.0004059788,0.00002661794,0.002937878],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003642361,"threshold_uncertainty_score":0.01218486,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03175407666708312,"score_gpt":0.3707638661550745,"score_spread":0.3390097894879914,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}