{"id":"W4415991569","doi":"10.3390/curroncol32110626","title":"Evolving Therapeutic Landscape of ROS1-Positive Non-Small Cell Lung Cancer: An Updated Review","year":2025,"lang":"en","type":"article","venue":"Current Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Crizotinib; ROS1; Lung cancer; Targeted therapy; Tyrosine kinase; Ceritinib; Protein-Tyrosine Kinases; Anaplastic lymphoma kinase; Disease","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006918724,0.0005382228,0.0009264784,0.001787088,0.0002095629,0.001090887,0.0005930685,0.0007805021,0.00180497],"category_scores_gemma":[0.001112652,0.0001917495,0.0005457459,0.001322282,0.0003084792,0.001547941,0.0004656845,0.001395725,0.0006162578],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007905252,"about_ca_system_score_gemma":0.001034836,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008109415,"about_ca_topic_score_gemma":0.001970132,"domain_scores_codex":[0.9997754,0.00004889393,0.00004576719,0.00003950669,0.00006870377,0.00002178575],"domain_scores_gemma":[0.9995302,0.0002538528,0.00007321992,0.000007642529,0.0001052791,0.00002966373],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009206079,0.00004974091,0.0004113766,0.01325206,0.0001112248,0.0002839055,0.00009219241,0.0004598133,0.001385607,0.002309028,0.03826801,0.943285],"study_design_scores_gemma":[0.00001884758,0.0001640863,0.001221897,0.005345454,0.0002607976,0.002157795,0.0001162071,0.0002436214,0.00050904,0.001417518,0.9885189,0.00002581102],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002599714,0.9979119,0.0001463031,0.0008743037,0.0002802219,0.000004002633,0.00001949397,0.000009138137,0.0004946199],"genre_scores_gemma":[0.001098154,0.9971855,0.0002985099,0.0005674764,0.0005124491,0.000006546399,0.00004729221,0.000002272391,0.0002817901],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00180497,"threshold_uncertainty_score":0.006038249,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03439287116426077,"score_gpt":0.4319434604115565,"score_spread":0.3975505892472957,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}