{"id":"W4415992105","doi":"10.1056/nejmoa2504187","title":"Oral Icotrokinra for Plaque Psoriasis in Adults and Adolescents","year":2025,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"XLV Diagnostics (Canada); Probity Medical Research; Innovaderm (Canada)","funders":"Johnson and Johnson","keywords":"Plaque psoriasis; Placebo; Psoriasis; Incidence (geometry); Peptide; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008516114,0.0003524463,0.001174017,0.0002370193,0.0002596913,0.0003585978,0.0002879979,0.0005958851,0.003136563],"category_scores_gemma":[0.0007825893,0.0002164509,0.0005703051,0.0001985099,0.0002926284,0.000224798,0.0002421326,0.001128236,0.0004010951],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002031215,"about_ca_system_score_gemma":0.0006308047,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005753282,"about_ca_topic_score_gemma":0.001126234,"domain_scores_codex":[0.999657,0.0001465089,0.00003619426,0.00004991356,0.00006048169,0.00004979389],"domain_scores_gemma":[0.9994671,0.0001317293,0.0001569726,0.00001638203,0.00004162089,0.0001863887],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.3516736,0.02166453,0.04689614,0.008660312,0.002683332,0.0008171254,0.0005379874,0.0009079443,0.05165454,0.0006199134,0.006319717,0.5075649],"study_design_scores_gemma":[0.433053,0.4125058,0.1138021,0.001786493,0.003344209,0.002132874,0.0004584005,0.0009764011,0.008705793,0.0003507623,0.0228457,0.00003836153],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.966334,0.0293591,0.0003942467,0.0005279323,0.0002200476,0.001005689,0.0002506455,0.00003912012,0.001869326],"genre_scores_gemma":[0.9836217,0.0121356,0.001199892,0.0006797375,0.0002601154,0.001159344,0.0001522713,0.0000064531,0.0007849462],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003136563,"threshold_uncertainty_score":0.01049286,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01170049343250594,"score_gpt":0.2596216156414172,"score_spread":0.2479211222089113,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}