{"id":"W4415992137","doi":"10.1056/nejmoa2510198","title":"A Phase 3 Trial of Atacicept in Patients with IgA Nephropathy","year":2025,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Renal Diseases and Glomerulopathies","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Placebo; Nephropathy; Proteinuria; Immunopathology; Clinical trial; Glomerulonephritis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003078759,0.00161854,0.002865155,0.0004693374,0.000613338,0.001208216,0.001269535,0.001672847,0.005688237],"category_scores_gemma":[0.001652758,0.000541157,0.001963693,0.0004759755,0.0008868095,0.001057873,0.0003810205,0.004236694,0.001045717],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007534896,"about_ca_system_score_gemma":0.001815135,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000686826,"about_ca_topic_score_gemma":0.001447411,"domain_scores_codex":[0.9992743,0.0003755304,0.0000423156,0.000121933,0.00006023254,0.0001256461],"domain_scores_gemma":[0.9985157,0.0003497728,0.0003022646,0.0001229222,0.0001495173,0.0005598806],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9299679,0.0188015,0.00178035,0.0007489194,0.00129582,0.0001361867,0.0001273623,0.000757802,0.008094562,0.0001908858,0.003110418,0.03498821],"study_design_scores_gemma":[0.9082222,0.08766987,0.002107434,0.00002358499,0.0002357733,0.00008001856,0.00001742145,0.0004072957,0.0004490737,0.00009788375,0.0006768822,0.00001246684],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9837475,0.00585525,0.0009915868,0.001217542,0.0007563553,0.003501368,0.001397152,0.0002605678,0.002272628],"genre_scores_gemma":[0.9846702,0.002489915,0.002491803,0.002301377,0.0005718052,0.003991738,0.001710965,0.00003945893,0.001732737],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005688237,"threshold_uncertainty_score":0.01902908,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008752399760786393,"score_gpt":0.2911680071931136,"score_spread":0.2824156074323272,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}