{"id":"W4415992352","doi":"10.1136/gutjnl-2025-336592","title":"Peginterferon alpha-2a add-on to siRNA JNJ-73763989 in untreated patients with HBeAg-positive chronic hepatitis B virus (HBV) infection: the phase 2 REEF-IT study","year":2025,"lang":"en","type":"article","venue":"Gut","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Janssen Biotech","keywords":"Chronic hepatitis; Virus; Hepatitis B virus; Interferon; Phases of clinical research; Phase (matter); Hepacivirus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001216822,0.0007503958,0.001156887,0.0002653211,0.0002959766,0.0005848664,0.0005013644,0.0007055666,0.003459351],"category_scores_gemma":[0.0006675479,0.0004442025,0.0008989868,0.0002846444,0.0005134245,0.00054007,0.0002254391,0.001315832,0.0008401477],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005558401,"about_ca_system_score_gemma":0.001075541,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001138998,"about_ca_topic_score_gemma":0.003152004,"domain_scores_codex":[0.9995732,0.0002405017,0.0000280406,0.00005579518,0.00004949812,0.00005303844],"domain_scores_gemma":[0.9995953,0.00005610194,0.0001515531,0.00002651613,0.00002807901,0.0001423798],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7317532,0.05602681,0.01257128,0.001247654,0.001459102,0.0003787384,0.00029152,0.001234326,0.04408922,0.0002509948,0.004311032,0.1463861],"study_design_scores_gemma":[0.6404935,0.3290245,0.02249838,0.00007869402,0.0006455226,0.0002535518,0.0000726682,0.0007641811,0.002341644,0.0001245578,0.003672627,0.0000303116],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934363,0.002238591,0.0002034627,0.0002357482,0.0001078171,0.00120225,0.000527073,0.0000464831,0.002002213],"genre_scores_gemma":[0.9911049,0.002294522,0.0007943949,0.0008143145,0.0001474989,0.001336033,0.0008555329,0.0000196498,0.00263321],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003459351,"threshold_uncertainty_score":0.01157272,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01174462413283497,"score_gpt":0.3118100386042547,"score_spread":0.3000654144714197,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}