{"id":"W4415992352","doi":"10.1136/gutjnl-2025-336592","title":"Peginterferon alpha-2a add-on to siRNA JNJ-73763989 in untreated patients with HBeAg-positive chronic hepatitis B virus (HBV) infection: the phase 2 REEF-IT study","year":2025,"lang":"en","type":"article","venue":"Gut","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Janssen Biotech","keywords":"Chronic hepatitis; Virus; Hepatitis B virus; Interferon; Phases of clinical research; Phase (matter); Hepacivirus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002203253,0.0003600531,0.0005456433,0.0003436629,0.0002502546,0.0000434282,0.0001478031,0.00008227401,0.0002146592],"category_scores_gemma":[0.0002584127,0.0002482759,0.00007345707,0.0008858737,0.0001096141,0.0001102132,0.0001544512,0.0003969368,0.0002827886],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001035563,"about_ca_system_score_gemma":0.0001875639,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.03233877,"about_ca_topic_score_gemma":0.2169771,"domain_scores_codex":[0.9978669,0.0002228744,0.0004560325,0.000565647,0.0004272067,0.0004613634],"domain_scores_gemma":[0.9987332,0.0002007855,0.0001062233,0.0005578609,0.0002856673,0.0001162412],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00174504,0.002479359,0.9648721,0.00004019993,0.0004717532,0.0001442315,0.002600824,0.00002757218,0.0001731931,0.00003053851,0.01168996,0.01572519],"study_design_scores_gemma":[0.009957335,0.0116198,0.9693854,0.0008536757,0.000253321,0.000003301461,0.00009605198,0.00007786641,0.00118979,0.000009253186,0.006309817,0.0002443427],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9889665,0.0001323942,0.00007721732,0.00166319,0.0003534874,0.002931327,0.00009618584,0.0001048972,0.00567481],"genre_scores_gemma":[0.9955898,0.0001241059,0.00001725907,0.001895559,0.0001389805,0.0004184207,0.0000639392,0.00003817396,0.001713759],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1846384,"threshold_uncertainty_score":0.999997,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01174462413283497,"score_gpt":0.3118100386042547,"score_spread":0.3000654144714197,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}