{"id":"W4415992375","doi":"10.1111/tra.70022","title":"Beyond the Secretory Pathway: New Insights Into Protein Release","year":2025,"lang":"en","type":"review","venue":"Traffic","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Centre National de la Recherche Scientifique; University of Chinese Academy of Sciences; Chinese Academy of Sciences; National and Kapodistrian University of Athens; Institute of Genetics; Universidade de São Paulo; Tsinghua University; University of Pennsylvania; Beijing University of Technology; Directorate for Biological Sciences; National Institutes of Health; Huazhong University of Science and Technology; University of Oxford; National Institute on Aging; Academia Sinica; Shenzhen Bay Laboratory; Sun Yat-sen University; School of Medicine, Emory University; Yonsei University; Institut National de la Santé et de la Recherche Médicale; Philipps-Universität Marburg; Harbin Medical University; Emory University; Université de Montpellier; Yale University","keywords":"Secretion; Endoplasmic reticulum; Golgi apparatus; Secretory protein; Secretory pathway; Extracellular; Cytoplasm; Signal peptide; Transport protein","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001158767,0.0003947397,0.0005721096,0.00007570742,0.0001297659,0.00003152467,0.0004234007,0.0005493039,0.00005263416],"category_scores_gemma":[0.0000248054,0.0002679,0.0005420964,0.0002010358,0.00007823031,0.000002243109,0.00005698323,0.0003387344,0.0000549741],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003039937,"about_ca_system_score_gemma":0.001209924,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001355192,"about_ca_topic_score_gemma":0.0001359986,"domain_scores_codex":[0.9985626,0.0001351631,0.0003926741,0.0005248846,0.0001586564,0.0002259792],"domain_scores_gemma":[0.9989988,0.00001571497,0.0001475513,0.0006876137,0.00003542465,0.0001149532],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002478566,0.00004218981,9.371277e-8,0.005569184,0.0001362379,0.00001939251,0.0001256912,0.000009272751,0.001135422,0.0002684476,0.001763325,0.9909059],"study_design_scores_gemma":[0.000157583,0.00007803179,3.406531e-7,0.001543212,0.0002363143,0.000005005721,0.00001026354,0.000004652803,0.0002636356,0.00006216598,0.9973345,0.0003043094],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0008385329,0.9962507,0.0005707619,0.00004624964,0.0002799102,0.001084187,0.00001201994,0.00003572374,0.0008818668],"genre_scores_gemma":[0.0003368827,0.9805819,0.00006633257,0.00008393078,0.0005968534,0.0001184831,0.007555547,0.00004731712,0.01061276],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9955711,"threshold_uncertainty_score":0.9999773,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01216924198078953,"score_gpt":0.2454197977487101,"score_spread":0.2332505557679206,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}