{"id":"W4416003752","doi":"10.1038/s41698-025-01106-1","title":"Co-clinical trial targeting ER, FGFR and CDK4/6 in resistant hormone-positive breast cancer with FGFR alterations","year":2025,"lang":"en","type":"article","venue":"npj Precision Oncology","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Instituto de Salud Carlos III; European Regional Development Fund; Bayer Canada; European Commission","keywords":"Fibroblast growth factor receptor; Breast cancer; Clinical trial; Acquired resistance; Endocrine system; Biomarker; Cancer","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001311351,0.000611929,0.0008889405,0.0002574967,0.00021098,0.0005738088,0.0003978674,0.0006682962,0.003648878],"category_scores_gemma":[0.0006618081,0.0001812454,0.0005966924,0.0002006201,0.0004280679,0.0005855712,0.0003601525,0.001410118,0.000641572],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005707178,"about_ca_system_score_gemma":0.0006591351,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004297649,"about_ca_topic_score_gemma":0.002128606,"domain_scores_codex":[0.9996333,0.0001634247,0.00002306023,0.00006267236,0.00003607238,0.00008129921],"domain_scores_gemma":[0.9996719,0.00006957309,0.00006051058,0.00003399305,0.00002324899,0.0001407161],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4692858,0.03878477,0.01065401,0.0008711751,0.001132895,0.0007064586,0.0003776757,0.003141679,0.184807,0.001036133,0.004631001,0.2845714],"study_design_scores_gemma":[0.2427787,0.676339,0.02428369,0.00007947029,0.0007578065,0.001208853,0.0001470934,0.003061079,0.03695977,0.0006935591,0.01365086,0.00004017311],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918101,0.002416324,0.0007367713,0.0004885052,0.0001243536,0.001280633,0.0004187923,0.00006829017,0.002656144],"genre_scores_gemma":[0.9926074,0.0009893168,0.001458578,0.0003123125,0.00006943962,0.0009039601,0.0008410104,0.00001554266,0.002802538],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003648878,"threshold_uncertainty_score":0.01220673,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02880004581935899,"score_gpt":0.4263399839146925,"score_spread":0.3975399380953336,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}