{"id":"W4416008053","doi":"10.1016/j.ejphar.2025.178347","title":"Brief topical application of TRPV3 channel agonist carvacrol mediates skin vasodilation via NOS, COX, and K+ channel pathways in young adults","year":2025,"lang":"en","type":"article","venue":"European Journal of Pharmacology","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Ministry of Education, Culture, Sports, Science and Technology","keywords":"Vasodilation; Carvacrol; Blockade; Agonist; Transient receptor potential channel; Nitric oxide","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002255127,0.0001787822,0.0004177122,0.0001017474,0.0001572795,0.0001969201,0.0000946544,0.0002687126,0.001563267],"category_scores_gemma":[0.0003327645,0.0001375043,0.0002029546,0.00004812384,0.0001789918,0.0002108374,0.0001338536,0.0004668152,0.0003030159],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001279934,"about_ca_system_score_gemma":0.0001373981,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005178403,"about_ca_topic_score_gemma":0.0009891037,"domain_scores_codex":[0.9999012,0.00001416002,0.000007636089,0.00003019179,0.00001810458,0.00002876237],"domain_scores_gemma":[0.9998411,0.00002732287,0.00003642499,0.000008018183,0.00002166142,0.00006538127],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01065933,0.002120148,0.04183404,0.0002820577,0.00004533793,0.001341052,0.0005154472,0.00005950227,0.9195299,0.00007484383,0.0005746666,0.02296366],"study_design_scores_gemma":[0.0003497684,0.07008173,0.8192911,0.00005552944,0.0001792581,0.002968305,0.0008216866,0.0005712775,0.1006171,0.0001093876,0.004931358,0.00002350807],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983509,0.0008971204,0.0002555307,0.00003635307,0.00002158463,0.00003465046,0.0001020818,0.000007943298,0.00029392],"genre_scores_gemma":[0.9978393,0.0006402051,0.0002617019,0.0001130314,0.00002899134,0.00006064934,0.0001566011,0.000002523588,0.0008970657],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001563267,"threshold_uncertainty_score":0.005229712,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01485715610825007,"score_gpt":0.2677927685408669,"score_spread":0.2529356124326168,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}