{"id":"W4416008662","doi":"10.1073/pnas.2512426122","title":"MDFIC2 is a PIEZO channel modulator that can alleviate mechanical allodynia associated with neuropathic pain","year":2025,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Erythrocyte Function and Pathophysiology","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Nautical Research Society","funders":"Renmin Hospital of Wuhan University; Faculty of Medicine, Assiut University; School of Pharmacy, University College London; Medical Research Council; Wuhan University; Zhejiang University; Centre National de la Recherche Scientifique; Universidad de Granada; Fonds National de la Recherche Luxembourg; National Natural Science Foundation of China; Institut National de la Santé et de la Recherche Médicale; Assiut University; European Commission; Qatar National Research Fund; Qatar Foundation; University College London; Wellcome Trust; Natural Science Foundation of Zhejiang Province; Aix-Marseille Université; Qatar University; National Institute for Health and Care Research","keywords":"Neuropathic pain; Mechanosensation; Allodynia; PIEZO1; Nociception; Gating; Sensory system; Nerve injury; Sensitivity (control systems)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008458877,0.0003004794,0.0003246215,0.000183835,0.0001987142,0.0001881839,0.0001941957,0.0003955539,0.001444012],"category_scores_gemma":[0.00007991734,0.00007384674,0.0001794718,0.0001448417,0.0001597423,0.0001718848,0.0001298805,0.0006981645,0.0001960334],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002528616,"about_ca_system_score_gemma":0.000239319,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005119252,"about_ca_topic_score_gemma":0.001034041,"domain_scores_codex":[0.9999393,0.000005093363,0.000003798384,0.00001167173,0.00002079245,0.00001930782],"domain_scores_gemma":[0.9999666,0.000003032965,0.000006338761,0.00000201325,0.000003414415,0.00001855053],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004411322,0.000175489,0.0002913602,0.0001289639,0.0000157862,0.0001672168,0.00001070324,0.0001063813,0.9915897,0.0001729698,0.0004718804,0.006428381],"study_design_scores_gemma":[0.0003413794,0.002495731,0.008866733,0.0000213415,0.00005582699,0.001339528,0.00003175658,0.001643006,0.9657896,0.0001454145,0.01925275,0.0000168502],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9726384,0.01287247,0.005274569,0.001017322,0.0003332697,0.000200006,0.001243487,0.0002843643,0.006136158],"genre_scores_gemma":[0.984252,0.004095825,0.004493212,0.0003603703,0.00007775136,0.0001666892,0.001566436,0.00001750817,0.004970234],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001444012,"threshold_uncertainty_score":0.004830718,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04456493543242542,"score_gpt":0.2887931181062525,"score_spread":0.244228182673827,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}