{"id":"W4416008662","doi":"10.1073/pnas.2512426122","title":"MDFIC2 is a PIEZO channel modulator that can alleviate mechanical allodynia associated with neuropathic pain","year":2025,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Erythrocyte Function and Pathophysiology","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Nautical Research Society","funders":"Renmin Hospital of Wuhan University; Faculty of Medicine, Assiut University; School of Pharmacy, University College London; Medical Research Council; Wuhan University; Zhejiang University; Centre National de la Recherche Scientifique; Universidad de Granada; Fonds National de la Recherche Luxembourg; National Natural Science Foundation of China; Institut National de la Santé et de la Recherche Médicale; Assiut University; European Commission; Qatar National Research Fund; Qatar Foundation; University College London; Wellcome Trust; Natural Science Foundation of Zhejiang Province; Aix-Marseille Université; Qatar University; National Institute for Health and Care Research","keywords":"Neuropathic pain; Mechanosensation; Allodynia; PIEZO1; Nociception; Gating; Sensory system; Nerve injury; Sensitivity (control systems)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002468819,0.0001187895,0.0002645568,0.0001837272,0.0001706341,0.00001096883,0.0003328669,0.0001339249,0.00002106221],"category_scores_gemma":[0.001646952,0.00007142995,0.00009058951,0.0008720469,0.0004835013,0.0001077388,0.00009083123,0.0002756235,9.314418e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004706428,"about_ca_system_score_gemma":0.0001050369,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007412174,"about_ca_topic_score_gemma":4.093548e-7,"domain_scores_codex":[0.9983684,0.00003574914,0.0002552756,0.0003012161,0.0008602019,0.0001790919],"domain_scores_gemma":[0.9990184,0.0002374883,0.0003168125,0.00001256937,0.0003638506,0.00005093612],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0006307425,0.0005921507,0.02649094,0.0005029143,0.0003735622,2.625616e-7,0.0009289092,0.0001607053,0.8984436,0.05726178,0.01302813,0.001586321],"study_design_scores_gemma":[0.003298529,0.00164232,0.4991789,0.002436297,0.0003092902,0.00005089312,0.00098564,0.07969721,0.3219151,0.08854324,0.001456784,0.0004857322],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9651962,0.00009512765,0.00002567711,0.03137799,0.00005751147,0.0003506606,0.0000190576,0.00003965089,0.002838134],"genre_scores_gemma":[0.9906167,0.00003522784,0.0001747115,0.008315839,0.00004330568,0.00001272586,4.95798e-7,0.000005333314,0.0007957108],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5765284,"threshold_uncertainty_score":0.2912829,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04456493543242542,"score_gpt":0.2887931181062525,"score_spread":0.244228182673827,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}