{"id":"W4416010574","doi":"10.1101/2025.11.05.686845","title":"Disruption of Cell-Type-Specific Molecular Programs of Medium Spiny Neurons in Autism","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Neurogenesis and neuroplasticity mechanisms","field":"Neuroscience","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"Health Data Research UK; Common Fund; California Institute for Regenerative Medicine; Simons Foundation","keywords":"Autism; Medium spiny neuron; Striatum; Transcriptome; Neuroanatomy; Autism spectrum disorder; Biological neural network; Neurotypical; Nerve net","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008597237,0.0002095907,0.0001884362,0.0004005284,0.0001433662,0.0002758516,0.0001175903,0.0001846166,0.0009485635],"category_scores_gemma":[0.000100349,0.0001228798,0.0002020187,0.0001796643,0.0001962902,0.0001351865,0.0002989475,0.0003058384,0.0002261357],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002116739,"about_ca_system_score_gemma":0.0001645961,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000715348,"about_ca_topic_score_gemma":0.002151697,"domain_scores_codex":[0.9999126,0.000005845554,0.000005593592,0.00003324544,0.00002872498,0.00001399554],"domain_scores_gemma":[0.9999598,0.000006324479,0.00001326164,0.000006772259,0.00000415936,0.000009646999],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000539807,0.000006618216,0.001969475,0.00002373302,0.000009557599,0.00009287839,0.0000232449,0.00008080389,0.9944359,0.0002152655,0.00006012187,0.00302841],"study_design_scores_gemma":[0.00001413506,0.0001137848,0.1434989,0.00002457804,0.00004714321,0.001066333,0.0001332586,0.002346367,0.8476019,0.0007650805,0.004377371,0.00001119765],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888318,0.0008411917,0.007220021,0.00006494818,0.00002158574,0.00001103904,0.001491075,0.0001768903,0.001341613],"genre_scores_gemma":[0.9887811,0.0007536628,0.005726059,0.00004657615,0.000005363641,0.00002943351,0.001884274,0.00005987555,0.002713629],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009485635,"threshold_uncertainty_score":0.003173292,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02521950592767432,"score_gpt":0.2374436375590213,"score_spread":0.212224131631347,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}