{"id":"W4416012194","doi":"10.1126/sciimmunol.aed4910","title":"Two of a kind, one with MS: Gut microbes tip the balance","year":2025,"lang":"en","type":"article","venue":"Science Immunology","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Microbiome; Autoimmunity; Balance (ability); Gut microbiome; Immune system; Inflammation; Dysbiosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002837177,0.00007970315,0.0001176133,0.00006571225,0.0001778666,0.00001347532,0.0005523454,0.00005644721,0.00001314614],"category_scores_gemma":[0.00004465309,0.00005285195,0.0000248098,0.0003667732,0.001562781,0.000003774327,0.0001802008,0.00009519347,0.000008121418],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001534544,"about_ca_system_score_gemma":0.0005250467,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002035476,"about_ca_topic_score_gemma":0.0001956288,"domain_scores_codex":[0.9992098,0.0000373852,0.0001364631,0.0002681972,0.00005974603,0.000288458],"domain_scores_gemma":[0.9993311,0.000011981,0.00007118386,0.0004451081,0.0001231904,0.00001748509],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005649861,0.00003508004,0.003526102,0.000008454512,0.00001963132,1.903292e-7,0.00005152845,0.000003827073,0.9936396,0.001773286,0.000260165,0.0006256475],"study_design_scores_gemma":[0.0005745152,0.0002965481,0.0759453,0.00003747921,0.00001061698,0.00001930525,0.0001482269,0.000005371869,0.909197,0.0001807752,0.01349583,0.00008901431],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928147,0.001385411,0.0003407053,0.001468944,0.0001721539,0.0001373423,0.000004473858,0.000005466105,0.003670825],"genre_scores_gemma":[0.9975954,0.0001891899,0.0008486817,0.0006954063,0.00002069362,0.000007782983,0.000004829523,0.000003685932,0.0006343811],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08444256,"threshold_uncertainty_score":0.575813,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005089060980257082,"score_gpt":0.2635279593237668,"score_spread":0.2584388983435097,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}