{"id":"W4416012194","doi":"10.1126/sciimmunol.aed4910","title":"Two of a kind, one with MS: Gut microbes tip the balance","year":2025,"lang":"en","type":"article","venue":"Science Immunology","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Microbiome; Autoimmunity; Balance (ability); Gut microbiome; Immune system; Inflammation; Dysbiosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001249904,0.001036076,0.001098257,0.001342133,0.003166077,0.002490756,0.0006511727,0.004596788,0.007947016],"category_scores_gemma":[0.01143284,0.0004757192,0.001226582,0.0006948549,0.002565695,0.003184807,0.002172611,0.006627581,0.00162484],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00108502,"about_ca_system_score_gemma":0.001353734,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003444277,"about_ca_topic_score_gemma":0.002654633,"domain_scores_codex":[0.9990314,0.0002444642,0.00007349202,0.0002518378,0.0001994378,0.0001993206],"domain_scores_gemma":[0.9975605,0.0004946939,0.0003537103,0.0003444628,0.0003859925,0.0008606383],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"observational","study_design_scores_codex":[0.009618253,0.00144114,0.1719678,0.001205814,0.001995276,0.1996545,0.01072334,0.0005276789,0.04773366,0.07823749,0.2886006,0.1882946],"study_design_scores_gemma":[0.0006716575,0.001502642,0.06350663,0.0012451,0.001109961,0.5620439,0.008441446,0.001289006,0.01598701,0.071272,0.2723832,0.000547367],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5223741,0.03651559,0.01263111,0.3613014,0.02898958,0.0002879708,0.002627907,0.001006034,0.0342663],"genre_scores_gemma":[0.7783803,0.01571021,0.01037866,0.1340124,0.008677428,0.0001926991,0.0009805863,0.0006944067,0.05097321],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007947016,"threshold_uncertainty_score":0.02658546,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005089060980257082,"score_gpt":0.2635279593237668,"score_spread":0.2584388983435097,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}