{"id":"W4416016123","doi":"10.7150/thno.119709","title":"Super-enhancer-driven core transcription factor FOXP1 delays endothelial cell senescence via phase separation-mediated SESN3 activation","year":2025,"lang":"en","type":"article","venue":"Theranostics","topic":"Single-cell and spatial transcriptomics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Aging","funders":"","keywords":"Senescence; Transcription factor; Endothelial stem cell; Cell cycle; Cell; Transcriptome; Chromatin; Endothelium","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000152796,0.0001602314,0.000144488,0.000109603,0.00008761797,0.0001840106,0.0001289517,0.0001354214,0.001369324],"category_scores_gemma":[0.0000985392,0.00009700924,0.0001221728,0.00007359913,0.0002213398,0.0001751714,0.0001673068,0.0005026713,0.0002054703],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003250451,"about_ca_system_score_gemma":0.0002625418,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004208885,"about_ca_topic_score_gemma":0.001267745,"domain_scores_codex":[0.9999338,0.000007328082,0.000002819462,0.00001678167,0.00002147071,0.00001768231],"domain_scores_gemma":[0.9999582,0.000007436774,0.00001309934,0.000003784156,0.000005694023,0.00001175528],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000691939,0.000008384516,0.00004916939,0.00001459292,0.00000130858,0.000007540918,0.000004808123,0.0000725206,0.9983318,0.0001839169,0.00004499558,0.00121173],"study_design_scores_gemma":[0.00001540458,0.00008245582,0.001031852,0.000002779577,0.000003803472,0.00002870443,0.00001167443,0.001541364,0.9953199,0.0001146707,0.001844689,0.00000263504],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9767351,0.002119523,0.0165895,0.0002684155,0.00006383227,0.00003374472,0.0005291034,0.0003053998,0.00335542],"genre_scores_gemma":[0.9932265,0.0005754115,0.003231137,0.00006693998,0.000008841754,0.00003534898,0.0002172789,0.00002778118,0.002610799],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001369324,"threshold_uncertainty_score":0.004580855,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01874893090458876,"score_gpt":0.2872178955851205,"score_spread":0.2684689646805317,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}