{"id":"W4416016225","doi":"10.7150/jca.124247","title":"Chemopreventive Targeting of Oncogenic Stemness: EGCG-Mediated Suppression of the HIF-1α-PPARγ-Cancer Stem Cells Transcriptional Signature in 3D Glioblastoma Spheroids","year":2025,"lang":"en","type":"article","venue":"Journal of Cancer","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; Université du Québec à Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Université du Québec à Montréal","keywords":"Downregulation and upregulation; Spheroid; Adipogenesis; Gene knockdown; Gene silencing; Transcriptome; Stem cell; Reprogramming; Cell culture; Peroxisome proliferator-activated receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007427139,0.0002760502,0.0002690366,0.0002749586,0.0001008878,0.0002178323,0.0000967897,0.0001666318,0.001081792],"category_scores_gemma":[0.00004653573,0.00009575873,0.0002308203,0.0001982061,0.000180663,0.000128047,0.0001131741,0.0005694141,0.0001799856],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002826168,"about_ca_system_score_gemma":0.0003179735,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002917589,"about_ca_topic_score_gemma":0.005722984,"domain_scores_codex":[0.9999503,0.000006644997,0.00000478834,0.00001161713,0.00001371024,0.0000129857],"domain_scores_gemma":[0.9999595,0.000007046816,0.000009723512,0.000006130676,0.000005560956,0.00001193345],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001143376,0.00002801975,0.00006470422,0.00002389447,0.000004851549,0.00002036284,0.00001913456,0.00008620399,0.9983813,0.0000646365,0.00005966593,0.00113288],"study_design_scores_gemma":[0.000007016044,0.0001124837,0.00134222,0.000002508298,0.000009975071,0.00002351034,0.00001988563,0.0002628757,0.9968099,0.00002367389,0.001384302,0.00000162461],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905098,0.001003177,0.004472834,0.0002646465,0.0000736285,0.00005405998,0.001383447,0.0002279679,0.002010334],"genre_scores_gemma":[0.9918528,0.0009349009,0.002536295,0.00009563857,0.000006019158,0.00004784485,0.0007296071,0.00004099786,0.003755962],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002917589,"threshold_uncertainty_score":0.005801201,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004922675851678999,"score_gpt":0.2524593855172733,"score_spread":0.2475367096655943,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}