{"id":"W4416016225","doi":"10.7150/jca.124247","title":"Chemopreventive Targeting of Oncogenic Stemness: EGCG-Mediated Suppression of the HIF-1α-PPARγ-Cancer Stem Cells Transcriptional Signature in 3D Glioblastoma Spheroids","year":2025,"lang":"en","type":"article","venue":"Journal of Cancer","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; Université du Québec à Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Université du Québec à Montréal","keywords":"Downregulation and upregulation; Spheroid; Adipogenesis; Gene knockdown; Gene silencing; Transcriptome; Stem cell; Reprogramming; Cell culture; Peroxisome proliferator-activated receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002865413,0.0001729933,0.0004244278,0.00008935948,0.00003885554,0.000007711663,0.0003392115,0.0002265599,0.0001386379],"category_scores_gemma":[0.00002429919,0.0001249604,0.0003294594,0.0003395558,0.0001192889,0.00001545857,0.00006312542,0.0003166964,2.064946e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007608708,"about_ca_system_score_gemma":0.0007015259,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005155953,"about_ca_topic_score_gemma":0.0002212566,"domain_scores_codex":[0.9984421,0.000123085,0.0006877658,0.000191575,0.0003485618,0.0002069608],"domain_scores_gemma":[0.998674,0.00002537686,0.000675812,0.0001743201,0.0003981955,0.00005226323],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009106312,0.0001106459,0.001530399,0.0001497663,0.0002173304,9.535034e-7,0.0002667068,0.001376703,0.9849927,0.00001004022,0.005306559,0.005127598],"study_design_scores_gemma":[0.00197049,0.0001012961,0.005286431,0.0006266526,0.0001345109,0.000002751082,0.0002634446,0.00003192569,0.9407492,0.00004637738,0.05066908,0.0001178964],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9151394,0.08121014,0.0001340404,0.0002277559,0.002873502,0.0001918853,0.0001177977,0.000001729952,0.0001037569],"genre_scores_gemma":[0.9906946,0.007164071,0.000145356,0.0001593899,0.000823689,0.00001647518,0.000003626726,0.0000176585,0.0009750678],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07555527,"threshold_uncertainty_score":0.5095739,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004922675851678999,"score_gpt":0.2524593855172733,"score_spread":0.2475367096655943,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}