{"id":"W4416020872","doi":"10.1016/j.clml.2025.10.014","title":"“Upfront Use of Blinatumomab in Adolescents and Adults With Philadelphia Chromosome: Negative B-cell Acute Lymphoblastic Leukemia: A Systematic Review and Proportional Meta-Analysis”","year":2025,"lang":"en","type":"review","venue":"Clinical Lymphoma Myeloma & Leukemia","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"","keywords":"Blinatumomab; Clinical trial; Meta-analysis; Chemotherapy; Minimal residual disease; Lymphoblastic Leukemia; Acute lymphocytic leukemia; Clinical endpoint","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003905836,0.001328421,0.00845076,0.002268402,0.0002806481,0.001610637,0.001258674,0.001541136,0.00428297],"category_scores_gemma":[0.01171268,0.001020465,0.01999393,0.003037384,0.0005642117,0.00120524,0.001150239,0.001964385,0.0002979752],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001612058,"about_ca_system_score_gemma":0.002007393,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007192684,"about_ca_topic_score_gemma":0.02453228,"domain_scores_codex":[0.9972225,0.001262406,0.000727032,0.0003680791,0.0002621547,0.0001577476],"domain_scores_gemma":[0.9955473,0.002671764,0.001255726,0.0001417903,0.0002702317,0.0001132254],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.007755938,0.00006618974,0.006810391,0.4591943,0.467442,0.0001213447,0.0001431029,0.00048106,0.0005112491,0.0002314953,0.002572337,0.05467063],"study_design_scores_gemma":[0.003727925,0.0005930188,0.008034991,0.03609403,0.9456685,0.0001272738,0.00007605372,0.0001355424,0.0001436969,0.0002288676,0.005131032,0.00003912398],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.004246884,0.9946491,0.0001529645,0.0001579774,0.0001382276,0.00007376006,0.0003778204,0.00001350408,0.0001897958],"genre_scores_gemma":[0.1925932,0.8029395,0.001058397,0.002036028,0.0002027261,0.0002278809,0.0005969221,0.00002222928,0.0003231784],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00845076,"threshold_uncertainty_score":0.02065629,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05662401907304467,"score_gpt":0.3581698320988692,"score_spread":0.3015458130258246,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}