{"id":"W4416021173","doi":"10.1002/ijc.70231","title":"Plasma proteomic profiling and molecular clustering reveal immune‐defined prognostic subtypes in lung adenocarcinoma","year":2025,"lang":"en","type":"article","venue":"International Journal of Cancer","topic":"Ferroptosis and cancer prognosis","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Vetenskapsrådet; Deutsches Zentrum für Lungenforschung; Max-Planck-Gesellschaft; Hessisches Ministerium für Wissenschaft und Kunst","keywords":"Immune system; Disease; Adenocarcinoma; Proteomics; Gene expression profiling; Lung; Transcriptome; Innate immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003848943,0.0001946301,0.0003404574,0.000920986,0.0003130987,0.0005307743,0.0001584917,0.0003356524,0.0004592492],"category_scores_gemma":[0.00110354,0.0001083521,0.0001985248,0.0006498598,0.0001740672,0.00018346,0.0002927682,0.0002251124,0.0001966175],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002004329,"about_ca_system_score_gemma":0.000176203,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001066296,"about_ca_topic_score_gemma":0.001288545,"domain_scores_codex":[0.9997835,0.00005624795,0.00002504796,0.00005032781,0.00004364307,0.00004128998],"domain_scores_gemma":[0.9996544,0.00006409695,0.0001447456,0.00003428534,0.00005369954,0.00004862957],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000894024,0.00007283025,0.9439518,0.00003377796,0.0001143668,0.0003012294,0.0002286537,0.0005360416,0.04222171,0.00006944416,0.000237228,0.01133889],"study_design_scores_gemma":[0.00001357061,0.000136975,0.9922934,0.000006234376,0.00003526343,0.0009406924,0.000251368,0.002609676,0.003076343,0.0001810068,0.0004469335,0.000008626525],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991885,0.0001969768,0.0003289863,0.000025084,0.000001967142,0.000005890111,0.0001060969,0.000006816612,0.0001396588],"genre_scores_gemma":[0.9992673,0.00006070562,0.0003805282,0.00001268297,0.000004312137,0.000005871013,0.0001788239,0.000002507765,0.00008731919],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001066296,"threshold_uncertainty_score":0.002120137,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01006699179574586,"score_gpt":0.2989866319286043,"score_spread":0.2889196401328584,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}