{"id":"W4416021546","doi":"10.1016/j.mex.2025.103712","title":"The BCG in situ study – novel techniques applied to a 100-year-old vaccine","year":2025,"lang":"en","type":"article","venue":"MethodsX","topic":"Immune responses and vaccinations","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Izaak Walton Killam Health Centre; Dalhousie University; University of British Columbia","funders":"Dalhousie University","keywords":"Vaccination; Tuberculosis; BCG vaccine; Immune system; Mycobacterium tuberculosis; Innate immune system; Intradermal injection; Tuberculosis vaccines","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004082468,0.0004632739,0.0002249646,0.0005836483,0.0002439696,0.000458769,0.0003210742,0.0006753674,0.001553166],"category_scores_gemma":[0.000229629,0.0003214595,0.0002584762,0.0003995607,0.000404546,0.0005157285,0.0004487718,0.0006790975,0.0006405184],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001944687,"about_ca_system_score_gemma":0.0001649858,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003197457,"about_ca_topic_score_gemma":0.0006325548,"domain_scores_codex":[0.9997671,0.0000545193,0.000009460824,0.00008200481,0.00005796535,0.00002906681],"domain_scores_gemma":[0.9998921,0.00002345729,0.00002969898,0.00001715969,0.00002040705,0.00001719791],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002862305,0.00001072694,0.0002544567,0.00004727945,0.000004221561,0.00003740808,0.00002870839,0.00004056541,0.9961733,0.0002065009,0.00005338664,0.00311474],"study_design_scores_gemma":[0.00000979653,0.0003090304,0.009746076,0.00003490448,0.00003459859,0.000778485,0.0001570987,0.002482469,0.9694481,0.0007235958,0.01625487,0.00002097072],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.6554345,0.02921097,0.2990163,0.001416857,0.0008098009,0.0002511711,0.001198593,0.0007449045,0.01191681],"genre_scores_gemma":[0.7934216,0.01735725,0.1713511,0.0009441177,0.0003312095,0.0003964736,0.001010933,0.0001959492,0.01499141],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.001553166,"threshold_uncertainty_score":0.005195916,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02179972221582107,"score_gpt":0.3541751318753708,"score_spread":0.3323754096595497,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}