{"id":"W4416021853","doi":"10.1016/s2214-109x(25)00415-2","title":"Effectiveness of the RTS,S/AS01E malaria vaccine in a real-world setting over 1 year of follow-up after the three-dose primary schedule: an interim analysis of a phase 4 study in Ghana, Kenya, and Malawi","year":2025,"lang":"en","type":"article","venue":"The Lancet Global Health","topic":"Malaria Research and Control","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Regional Municipality of Waterloo","funders":"Kenya Medical Research Institute; GlaxoSmithKline","keywords":"Interim analysis; Interim; Malaria; Malaria vaccine; Phase (matter); MEDLINE","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0134114,0.001679376,0.001936325,0.0006464607,0.0004914405,0.0008932843,0.0009513529,0.001109978,0.001417402],"category_scores_gemma":[0.009510575,0.000763397,0.003722499,0.0006639223,0.001097452,0.001081336,0.0008183027,0.001631254,0.0003202686],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001107752,"about_ca_system_score_gemma":0.001623667,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001634456,"about_ca_topic_score_gemma":0.001363703,"domain_scores_codex":[0.9950557,0.003212896,0.0002465244,0.0003812899,0.0004215959,0.0006820692],"domain_scores_gemma":[0.9920321,0.002244733,0.002975991,0.001374936,0.0007763432,0.000595964],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.6643238,0.02402073,0.2320032,0.0009808367,0.00825986,0.0004564452,0.001321013,0.009805225,0.01025864,0.0002844271,0.001679428,0.04660628],"study_design_scores_gemma":[0.04975259,0.4599128,0.4717847,0.0001333675,0.006141436,0.0003922608,0.000361471,0.003984527,0.004739773,0.0003021685,0.002402893,0.00009206076],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970973,0.0005541864,0.0004718758,0.0000479537,0.00001419137,0.000675912,0.0008639354,0.00001581092,0.0002590533],"genre_scores_gemma":[0.9957106,0.0001735978,0.0007682064,0.00005928146,0.00002574736,0.0011338,0.001814698,0.000006545787,0.0003075832],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0134114,"threshold_uncertainty_score":0.07092714,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02063056849584595,"score_gpt":0.3897939431631157,"score_spread":0.3691633746672697,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}