{"id":"W4416024141","doi":"10.1016/j.jtct.2025.11.008","title":"Toward Better and More Effective Clinical Trials for Chronic Graft-Versus-Host Disease","year":2025,"lang":"en","type":"article","venue":"Transplantation and Cellular Therapy","topic":"Hematopoietic Stem Cell Transplantation","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Children's Hospital","funders":"","keywords":"Clinical trial; Observational study; Disease; Biomarker; Intervention (counseling); Precision medicine; Clinical study design; Clinical endpoint","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.09797156,0.001475752,0.005376552,0.001847524,0.001393308,0.006497873,0.002023686,0.006101751,0.007704756],"category_scores_gemma":[0.03305347,0.0005433117,0.002026831,0.001489678,0.003572668,0.006710124,0.002190879,0.008703852,0.00155546],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002262616,"about_ca_system_score_gemma":0.009558325,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007692417,"about_ca_topic_score_gemma":0.001618943,"domain_scores_codex":[0.9634975,0.02972074,0.002946993,0.001116872,0.001727235,0.0009906371],"domain_scores_gemma":[0.9594851,0.02315512,0.005657787,0.002194686,0.005195518,0.004311847],"domain_codex":null,"domain_gemma":"methods","domain_candidate":"methods","domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.06844939,0.02153869,0.01293223,0.01697662,0.002402436,0.0005010249,0.0009685854,0.004405498,0.05873387,0.05034839,0.03985645,0.7228869],"study_design_scores_gemma":[0.1667389,0.1935329,0.02603588,0.02578992,0.005891518,0.001255398,0.002661727,0.005346167,0.03036588,0.08020152,0.4617828,0.0003974225],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"review","genre_gemma":"commentary","genre_scores_codex":[0.122816,0.4576278,0.08625681,0.2611679,0.01886655,0.02468363,0.002960237,0.0004821764,0.02513899],"genre_scores_gemma":[0.3314997,0.1980579,0.2082758,0.1947391,0.02270987,0.03155119,0.004385839,0.0003318604,0.008448703],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.9020284,"threshold_uncertainty_score":0.5181293,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0921127108918568,"score_gpt":0.4018105976780595,"score_spread":0.3096978867862027,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}