{"id":"W4416024458","doi":"10.1016/j.xcrm.2025.102449","title":"Integrated immune, hormonal, and transcriptomic profiling reveals sex-specific dysregulation in long COVID patients with ME/CFS","year":2025,"lang":"en","type":"article","venue":"Cell Reports Medicine","topic":"Fibromyalgia and Chronic Fatigue Syndrome Research","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women and Children’s Health Research Institute; University of Alberta","funders":"Faculty of Medicine and Dentistry, University of Alberta; Arthritis Society; Li Ka Shing Institute of Virology, University of Alberta; Institute of Infection and Immunity; Canadian Institutes of Health Research; University of Alberta; Canada Foundation for Innovation","keywords":"Transcriptome; Immune system; Erythropoiesis; Hormone; Gene expression profiling; Coronavirus disease 2019 (COVID-19); Cytokine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001872553,0.0002644458,0.0004700609,0.0005531895,0.0003531498,0.0005458494,0.0001205937,0.0003351977,0.001674873],"category_scores_gemma":[0.0004818499,0.0001099424,0.0003132752,0.0004799144,0.0001772021,0.0001989225,0.0002879438,0.0003310434,0.0002168991],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002186991,"about_ca_system_score_gemma":0.0001569422,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001254851,"about_ca_topic_score_gemma":0.002659248,"domain_scores_codex":[0.9998325,0.00002374919,0.00001629099,0.00005167627,0.00002545536,0.00005024438],"domain_scores_gemma":[0.9998133,0.00003339438,0.00006395154,0.00001244788,0.00003395081,0.00004295232],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002256546,0.00008200871,0.9049205,0.0001833672,0.0002485588,0.001860903,0.0004712637,0.0001922345,0.05425949,0.00008835331,0.00111883,0.03431782],"study_design_scores_gemma":[0.00002046122,0.000298811,0.9941261,0.00003770341,0.00008120909,0.00171128,0.0004413023,0.0001958402,0.001376364,0.0001184378,0.001578538,0.00001392781],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940053,0.002933889,0.0003526158,0.0001512161,0.0000237984,0.00001848407,0.001756869,0.00001384077,0.0007440137],"genre_scores_gemma":[0.9969392,0.0005843292,0.0003166426,0.0001687246,0.00003136514,0.00002623529,0.001426711,0.000007616352,0.0004993224],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001674873,"threshold_uncertainty_score":0.005602956,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01336195849979088,"score_gpt":0.2660634296061539,"score_spread":0.252701471106363,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}