{"id":"W4416027282","doi":"10.1016/j.ard.2025.10.011","title":"CD3+ immune cell endotypes are associated with PsA disease phenotype and response to advanced therapy: an integrated mass cytometry and proteomics cohort study","year":2025,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; Krembil Foundation; University of Waterloo; University of Toronto; Women's College Hospital","funders":"Canada Research Chairs; National Psoriasis Foundation","keywords":"Immune system; Mass cytometry; Proteomics; Phenotype; Disease; Cell; Cohort study; Flow cytometry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005411476,0.000272752,0.000507432,0.0001800339,0.0003423894,0.00004220154,0.0003754719,0.00007015975,0.00002883303],"category_scores_gemma":[0.0009907658,0.0001769055,0.00007765256,0.0005222178,0.0003306303,0.0001396061,0.0001313479,0.0001630803,0.00000399702],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000169215,"about_ca_system_score_gemma":0.00018004,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007849425,"about_ca_topic_score_gemma":0.00000605372,"domain_scores_codex":[0.9980797,0.0007888744,0.0003890603,0.0003504845,0.00008723159,0.0003046733],"domain_scores_gemma":[0.9985476,0.0003616407,0.0002797941,0.000591177,0.0001891065,0.0000306803],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.04812946,0.009835667,0.7604942,0.0004079446,0.003481883,0.00001184195,0.005338315,0.0004727424,0.1141401,0.0002111173,0.0001902518,0.05728646],"study_design_scores_gemma":[0.002338829,0.0006051317,0.9851857,0.0005586258,0.0001787039,4.784717e-7,0.004440505,0.00002298527,0.006008147,0.0003439581,0.00008790057,0.0002289653],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9702467,0.02719729,0.00007446686,0.0004456373,0.0001162387,0.00166845,0.0001619616,0.00005707644,0.00003215257],"genre_scores_gemma":[0.9984893,0.0004285965,0.00001749544,0.0002388333,4.61378e-7,0.000142995,0.00004457047,0.0000199574,0.0006177764],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2246915,"threshold_uncertainty_score":0.7213995,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01060389839814718,"score_gpt":0.257016342580533,"score_spread":0.2464124441823858,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}