{"id":"W4416032932","doi":"10.1002/hbm.70406","title":"Brain Connectivity Gradients Alterations in Discordant Cerebrospinal Fluid Profile for Alzheimer's Disease Biomarkers","year":2025,"lang":"en","type":"article","venue":"Human Brain Mapping","topic":"Functional Brain Connectivity Studies","field":"Neuroscience","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Genentech; National Institutes of Health; Eisai Canada; H. Lundbeck A/S; Servier; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Northern California Institute for Research and Education; Alzheimer's Association; Fujirebio US; DoD Alzheimer's Disease Neuroimaging Initiative; Pfizer; Biogen; BioClinica; Eisai; Fondazione Cassa di Risparmio di Padova e Rovigo; F. Hoffmann-La Roche; University of Southern California; Ministero della Salute; Novartis Pharmaceuticals Corporation; Alzheimer's Drug Discovery Foundation; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; Foundation for the National Institutes of Health; GE Healthcare; Alzheimer's Disease Neuroimaging Initiative; Ministero dell’Istruzione, dell’Università e della Ricerca; Takeda Pharmaceutical Company; AbbVie; National Science Foundation","keywords":"Cerebrospinal fluid; Diffusion MRI; Logistic regression; Discriminative model; Connectome; Functional connectivity; Neuroimaging; Linear regression; Brain mapping; Disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005288868,0.0003629356,0.0003383732,0.001118856,0.000288451,0.0005574679,0.000281811,0.0002492855,0.001774776],"category_scores_gemma":[0.003460525,0.0001051946,0.0002758679,0.0005695077,0.0002998501,0.0003747133,0.0004529899,0.0001982277,0.0002747497],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002134585,"about_ca_system_score_gemma":0.0002136819,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002005587,"about_ca_topic_score_gemma":0.003821464,"domain_scores_codex":[0.9997194,0.00006783173,0.00003145138,0.00009035751,0.00005334531,0.00003746531],"domain_scores_gemma":[0.9992707,0.0002341918,0.0002474558,0.00009001513,0.0001105608,0.0000470554],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003471933,0.0002187571,0.8533742,0.0003238609,0.0006884377,0.001217917,0.001391729,0.002904705,0.06208349,0.001357831,0.003395756,0.06957141],"study_design_scores_gemma":[0.00003054579,0.000266188,0.981804,0.00003683046,0.0001634266,0.001518157,0.0003227837,0.00734542,0.005115771,0.002183436,0.001185789,0.00002768874],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955699,0.0001645468,0.002302334,0.00004882115,0.000007912549,0.00003116632,0.001240761,0.00005472165,0.0005797663],"genre_scores_gemma":[0.9965543,0.00006291088,0.001955788,0.00001497634,0.000009663682,0.00005290862,0.001124348,0.00001915437,0.0002060625],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002005587,"threshold_uncertainty_score":0.005937278,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05926599119443546,"score_gpt":0.3159187998462175,"score_spread":0.2566528086517821,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}