{"id":"W4416032932","doi":"10.1002/hbm.70406","title":"Brain Connectivity Gradients Alterations in Discordant Cerebrospinal Fluid Profile for Alzheimer's Disease Biomarkers","year":2025,"lang":"en","type":"article","venue":"Human Brain Mapping","topic":"Functional Brain Connectivity Studies","field":"Neuroscience","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Genentech; National Institutes of Health; Eisai Canada; H. Lundbeck A/S; Servier; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Northern California Institute for Research and Education; Alzheimer's Association; Fujirebio US; DoD Alzheimer's Disease Neuroimaging Initiative; Pfizer; Biogen; BioClinica; Eisai; Fondazione Cassa di Risparmio di Padova e Rovigo; F. Hoffmann-La Roche; University of Southern California; Ministero della Salute; Novartis Pharmaceuticals Corporation; Alzheimer's Drug Discovery Foundation; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; Foundation for the National Institutes of Health; GE Healthcare; Alzheimer's Disease Neuroimaging Initiative; Ministero dell’Istruzione, dell’Università e della Ricerca; Takeda Pharmaceutical Company; AbbVie; National Science Foundation","keywords":"Cerebrospinal fluid; Diffusion MRI; Logistic regression; Discriminative model; Connectome; Functional connectivity; Neuroimaging; Linear regression; Brain mapping; Disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow","sts"],"consensus_categories":[],"category_scores_codex":[0.0006792528,0.0003130035,0.0003305118,0.0005332508,0.001353056,0.0001615354,0.0003231851,0.00004650347,0.00003470705],"category_scores_gemma":[0.01512515,0.0003350588,0.0001783419,0.0008058485,0.0002937412,0.000405645,0.0002336238,0.0001943687,0.00001694287],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001953494,"about_ca_system_score_gemma":0.0001455568,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006598153,"about_ca_topic_score_gemma":0.0002407033,"domain_scores_codex":[0.9973026,0.0003377956,0.0004275786,0.00106252,0.0002718158,0.0005976949],"domain_scores_gemma":[0.9915656,0.007676844,0.0001282492,0.0004338308,0.00006843782,0.000126989],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003075346,0.0007182166,0.01992192,0.0002753521,0.0001814134,0.00005007951,0.0008953282,0.0002621945,0.6401412,0.1728128,0.1633007,0.001133331],"study_design_scores_gemma":[0.004916656,0.0003546381,0.8435985,0.0007964536,0.0000940884,0.00001086095,0.001078616,0.01512948,0.01543152,0.0752006,0.04239771,0.0009908788],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9211223,0.0003036553,0.01679793,0.05159702,0.001219889,0.003550908,0.0003109905,0.0003343296,0.00476303],"genre_scores_gemma":[0.9894565,0.000002348485,0.0003151359,0.007888031,0.0001151153,0.0009658955,0.00003890621,0.00003042635,0.00118761],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8236766,"threshold_uncertainty_score":0.9999471,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05926599119443546,"score_gpt":0.3159187998462175,"score_spread":0.2566528086517821,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}