{"id":"W4416038792","doi":"10.1038/s41388-025-03623-6","title":"Regulation of ribosomal gene expression and senescence by a PML-mTOR-RONIN nuclear complex in triple-negative breast cancer","year":2025,"lang":"en","type":"article","venue":"Oncogene","topic":"Retinoids in leukemia and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; McGill University Health Centre","funders":"","keywords":"Gene silencing; Senescence; Carcinogenesis; Phenotype; Gene expression; Cancer; Breast cancer; Downregulation and upregulation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008829465,0.0001184861,0.0001598084,0.00003969283,0.00004976812,0.00001020695,0.000111764,0.00013378,0.00003864246],"category_scores_gemma":[0.00002760894,0.0001132803,0.00003231868,0.0001309195,0.0001116009,0.000005797345,0.00009436357,0.00005679241,6.308557e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003428446,"about_ca_system_score_gemma":0.00009694342,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001432163,"about_ca_topic_score_gemma":0.00002631137,"domain_scores_codex":[0.9992073,0.00006348002,0.0002047656,0.0002913247,0.00009305406,0.0001401284],"domain_scores_gemma":[0.9996374,0.00001092439,0.00009686581,0.000147028,0.00007255148,0.00003526469],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002101249,0.00005023974,0.004780079,0.00004679822,0.00001733281,8.594553e-7,0.00005680017,0.00002637606,0.9899576,0.00002104388,0.001548396,0.003284292],"study_design_scores_gemma":[0.001129088,0.00006344305,0.009916435,0.00009121288,0.00001376074,0.000006892758,0.00006468102,0.0002667714,0.9870121,0.00006408,0.001255458,0.000116105],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996563,0.001750833,0.0006431412,0.0001228114,0.00005201126,0.0001479911,0.00009307927,0.000006073293,0.0006210936],"genre_scores_gemma":[0.9972642,0.0007255076,0.001099787,0.00007561858,0.00005296537,0.00001510785,0.00008097674,0.00001187206,0.0006739567],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005136357,"threshold_uncertainty_score":0.4619436,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006458873303693131,"score_gpt":0.2521185548474547,"score_spread":0.2456596815437615,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}