{"id":"W4416039303","doi":"10.1056/nejmoa2512761","title":"Olezarsen for Managing Severe Hypertriglyceridemia and Pancreatitis Risk","year":2025,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Pancreatitis Pathology and Treatment","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Université du Québec à Chicoutimi","funders":"Ionis Pharmaceuticals","keywords":"Hypertriglyceridemia; Pancreatitis; Incidence (geometry); Acute pancreatitis; Triglycerides blood; Triglyceride","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007696901,0.0004757709,0.000997782,0.0003262236,0.0001326724,0.0003646698,0.000253934,0.0004150296,0.001422274],"category_scores_gemma":[0.0009165538,0.0001279397,0.0007751639,0.000453864,0.0002173815,0.0002928477,0.0002994787,0.0007252216,0.0001785089],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002622333,"about_ca_system_score_gemma":0.0005619292,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002479351,"about_ca_topic_score_gemma":0.0005560351,"domain_scores_codex":[0.9997267,0.0001229811,0.00004611806,0.00002802726,0.00004591123,0.00003030848],"domain_scores_gemma":[0.9996044,0.0001010642,0.0001928063,0.00001712595,0.00002130595,0.00006327554],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.1919867,0.003389477,0.03361731,0.006255225,0.004243956,0.001448648,0.0001839548,0.002202454,0.02469042,0.001074035,0.007042973,0.7238648],"study_design_scores_gemma":[0.4290658,0.1536965,0.2790921,0.003624315,0.01166408,0.01230432,0.0003758059,0.006516586,0.02158119,0.004592238,0.07728123,0.0002057962],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7732445,0.2158585,0.001340907,0.002724062,0.0003968384,0.0006192474,0.0003033052,0.0001082775,0.005404387],"genre_scores_gemma":[0.9352329,0.05760071,0.002363886,0.001912414,0.0006770805,0.0004275935,0.0004824638,0.00001143698,0.001291578],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001422274,"threshold_uncertainty_score":0.004758,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01155853051843018,"score_gpt":0.2835708471302985,"score_spread":0.2720123166118683,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}