{"id":"W4416041942","doi":"10.1056/nejmoa2512133","title":"Sibeprenlimab in IgA Nephropathy — Interim Analysis of a Phase 3 Trial","year":2025,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Renal Diseases and Glomerulopathies","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hamilton Health Sciences; McMaster University; Population Health Research Institute","funders":"","keywords":"Proteinuria; Nephropathy; Placebo; Interim analysis; Phase (matter); Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.009604824,0.001529625,0.003417247,0.000426215,0.0006043662,0.001891886,0.000860507,0.001806519,0.005110552],"category_scores_gemma":[0.005784098,0.0004750154,0.004887579,0.0004941216,0.0007095271,0.001225932,0.000573254,0.002897583,0.001027158],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007212366,"about_ca_system_score_gemma":0.002325696,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003829654,"about_ca_topic_score_gemma":0.0008179831,"domain_scores_codex":[0.9972219,0.001753274,0.0001571929,0.0002146299,0.0002108585,0.0004421],"domain_scores_gemma":[0.9962493,0.001260472,0.0008674436,0.0005509381,0.0003424422,0.0007295185],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9549521,0.003513818,0.002048007,0.0008041203,0.003827135,0.0001749488,0.00009020873,0.001361543,0.003477009,0.0002775558,0.004616796,0.02485674],"study_design_scores_gemma":[0.8857396,0.09606265,0.007541699,0.0001639645,0.003251268,0.0002088697,0.00003823287,0.001826173,0.00116807,0.001047999,0.002902247,0.00004928242],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9394849,0.01739731,0.007440108,0.003968821,0.001958386,0.01280467,0.007611575,0.000810864,0.008523402],"genre_scores_gemma":[0.9597425,0.003036306,0.006399686,0.004508499,0.0009346643,0.01549613,0.00608938,0.0001332061,0.003659708],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009604824,"threshold_uncertainty_score":0.05079579,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.021696773213277,"score_gpt":0.3578986808126132,"score_spread":0.3362019075993362,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}