{"id":"W4416041944","doi":"10.1001/jamacardio.2025.4477","title":"Efficacy of Acoramidis in Wild-Type and Variant Transthyretin Amyloid Cardiomyopathy","year":2025,"lang":"en","type":"article","venue":"JAMA Cardiology","topic":"Amyloidosis: Diagnosis, Treatment, Outcomes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"AstraZeneca; Alnylam Pharmaceuticals; Pfizer","keywords":"Transthyretin; Cardiomyopathy; Amyloid (mycology); Cardiac amyloidosis; Heart failure; Amyloidosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001512133,0.0006085154,0.001181406,0.0004282754,0.0002556491,0.0006275552,0.0005304461,0.0008962033,0.001831055],"category_scores_gemma":[0.001504208,0.0002350121,0.0008192827,0.0002609305,0.0004538578,0.0006793319,0.0002415769,0.00110206,0.0002290603],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003954234,"about_ca_system_score_gemma":0.0005000226,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000442234,"about_ca_topic_score_gemma":0.001119339,"domain_scores_codex":[0.999541,0.0002248956,0.0000533875,0.0000615633,0.00007264328,0.00004645549],"domain_scores_gemma":[0.9991986,0.0002291052,0.0002572285,0.00004807933,0.00006928205,0.0001976333],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8793586,0.01927811,0.005935607,0.0010542,0.001070734,0.0001183513,0.0001174033,0.0004916023,0.01789928,0.0001437407,0.0005785192,0.07395387],"study_design_scores_gemma":[0.4430521,0.5115823,0.0361339,0.0001605533,0.001048276,0.0003083747,0.0001244726,0.001497736,0.004195327,0.0002701893,0.001587897,0.00003889664],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944283,0.004213569,0.0001071731,0.0001002717,0.00006676535,0.0002165453,0.0001522744,0.00002294238,0.0006922064],"genre_scores_gemma":[0.9974497,0.001179619,0.000284829,0.0001633535,0.0001308193,0.0001983544,0.0001990802,0.000004512745,0.0003897062],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001831055,"threshold_uncertainty_score":0.007997036,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006960735473542937,"score_gpt":0.2551533670598834,"score_spread":0.2481926315863405,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}