{"id":"W4416046516","doi":"10.1210/endocr/bqaf162","title":"Glucagon, the Alpha Cell, and Potential Targets for Diabetes Treatment","year":2025,"lang":"en","type":"review","venue":"Endocrinology","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lawson Health Research Institute; Western University","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Natural Sciences and Engineering Research Council of Canada","keywords":"Hyperglucagonemia; Alpha cell; Glucagon; Alpha (finance); Paracrine signalling; Secretion; Intracellular; Beta cell; Diabetes mellitus; Intracrine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004437619,0.0005524942,0.0009340015,0.001166767,0.0002003666,0.0008756855,0.0006506277,0.0008515928,0.006360125],"category_scores_gemma":[0.0004962071,0.0001450874,0.0003516161,0.0008566052,0.0002721951,0.00116775,0.0005726314,0.002297511,0.003485088],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004174712,"about_ca_system_score_gemma":0.0006186583,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003564063,"about_ca_topic_score_gemma":0.000851889,"domain_scores_codex":[0.9998732,0.00002526287,0.00001586274,0.00001768193,0.00004971122,0.00001828815],"domain_scores_gemma":[0.9998413,0.00005668028,0.00002154587,0.000004622438,0.0000456509,0.00003009331],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001288172,0.0000826258,0.000125151,0.01006752,0.00006075832,0.0002603793,0.00004000876,0.0002129431,0.002427392,0.005300093,0.06760268,0.9136917],"study_design_scores_gemma":[0.00001647661,0.00007302161,0.0003490838,0.00215117,0.000043738,0.000788958,0.00003473023,0.0000446121,0.0002286758,0.002175553,0.9940842,0.000009827719],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00009550791,0.997366,0.0001075095,0.0005649956,0.0005605121,0.000003838704,0.00002342766,0.00001038248,0.00126794],"genre_scores_gemma":[0.0005177402,0.9972665,0.0001623355,0.0005053644,0.0004325294,0.000006447404,0.00005322777,0.000002165136,0.001053771],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.006360125,"threshold_uncertainty_score":0.02127671,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02481863944716639,"score_gpt":0.3136287156939554,"score_spread":0.288810076246789,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}