{"id":"W4416063206","doi":"10.1111/nph.70712","title":"A cell‐type‐specific regulon controlling monoterpene indole alkaloid biosynthesis with feedback and feedforward activation loops","year":2025,"lang":"en","type":"article","venue":"New Phytologist","topic":"Plant Gene Expression Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia, Okanagan Campus","funders":"Catalyst @ Health 2.0; Division of Molecular and Cellular Biosciences; Natural Sciences and Engineering Research Council of Canada; University of Minnesota; University of California, Davis; Georgia Research Alliance; University of Georgia; National Science Foundation","keywords":"Regulon; Gene; Biosynthesis; MYB; Elicitor; Metabolic pathway; Sanguinarine; Catharanthus roseus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001017503,0.0002596678,0.0002770144,0.0001966336,0.0002078809,0.0002834996,0.0001769186,0.0002276699,0.0008008841],"category_scores_gemma":[0.0001316888,0.0002337294,0.0003384589,0.0001296364,0.0001579427,0.0002666459,0.0003078881,0.0003273601,0.0002997566],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002113771,"about_ca_system_score_gemma":0.000213013,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001258499,"about_ca_topic_score_gemma":0.001880147,"domain_scores_codex":[0.9998767,0.000007191144,0.000004875749,0.00006565661,0.00002118056,0.00002430557],"domain_scores_gemma":[0.9998906,0.00002501722,0.00002581125,0.00001375204,0.00001905549,0.00002574169],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002680413,0.00000298493,0.0006976317,0.00001485779,0.00000173732,0.00002219093,0.0000249807,0.00009286024,0.9980634,0.00008058847,0.00002021411,0.0009518151],"study_design_scores_gemma":[0.00003760414,0.0001741081,0.1322184,0.00002213806,0.00006745405,0.0004918676,0.0002034451,0.02775645,0.8311571,0.0004758464,0.007350299,0.00004523152],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.983198,0.000587882,0.01305524,0.00004839522,0.00002173801,0.00003361994,0.0009972947,0.0003800441,0.001677824],"genre_scores_gemma":[0.9896737,0.0002155965,0.006944588,0.00006149519,0.00001052378,0.00004145463,0.001113271,0.00006920245,0.001870038],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001258499,"threshold_uncertainty_score":0.002679229,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008419163216811111,"score_gpt":0.2269977198699241,"score_spread":0.218578556653113,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}