{"id":"W4416073030","doi":"10.1016/j.jid.2025.09.209","title":"204 Inhibition of Structural Damage Progression With Guselkumab, a Selective IL-23i, in Participants With Active PsA: Results Through Week 24 of the Phase 3b APEX Study","year":2025,"lang":"en","type":"article","venue":"Journal of Investigative Dermatology","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Memorial University of Newfoundland","funders":"","keywords":"Apex (geometry); Psoriatic arthritis; Phases of clinical research; Arthritis; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001233426,0.0006711023,0.00127423,0.0002312159,0.0003922131,0.0007627938,0.0005275905,0.0007234212,0.003793298],"category_scores_gemma":[0.000563884,0.0003213305,0.001422585,0.0002228666,0.000432171,0.0005182461,0.0002277869,0.002036202,0.0008393116],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004372413,"about_ca_system_score_gemma":0.0008497969,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001048654,"about_ca_topic_score_gemma":0.003207634,"domain_scores_codex":[0.9996393,0.0001440089,0.00001764979,0.00004880287,0.00006255575,0.00008764785],"domain_scores_gemma":[0.9995878,0.00007292572,0.00008524255,0.00003918931,0.00005338938,0.0001615025],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.635321,0.03506998,0.009064319,0.001391904,0.00245848,0.0001565366,0.0002593854,0.0008744535,0.09254848,0.0001850289,0.003807185,0.2188633],"study_design_scores_gemma":[0.2492483,0.6461384,0.07751146,0.0001616377,0.002080274,0.0002776177,0.0002835063,0.0009223188,0.01787636,0.0004085118,0.00501402,0.00007759281],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913146,0.004824857,0.0005085135,0.0003778148,0.000100828,0.0005354535,0.0008578898,0.00007513689,0.001404953],"genre_scores_gemma":[0.9931576,0.002128673,0.00102019,0.0004467838,0.0000959863,0.0004010645,0.0006510342,0.00002306271,0.002075594],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003793298,"threshold_uncertainty_score":0.01268983,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03494254464096976,"score_gpt":0.3117873752304605,"score_spread":0.2768448305894907,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}