{"id":"W4416084814","doi":"10.1093/neuonc/noaf201.0077","title":"ANGI-11. MESENCHYMAL STEM CELLS AND PERIVASCULAR STROMA ARE ASSOCIATED WITH MICROVASCULAR PROLIFERATION, IMMUNOSUPPRESSION, AND POOR OUTCOME IN GLIOMA","year":2025,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Single-cell and spatial transcriptomics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Mesenchymal stem cell; PDGFRB; Stromal cell; Glioma; Transcriptome; Immune system; CD34; Stem cell; Single-cell analysis; Gene signature","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002350515,0.0002410661,0.0004043967,0.0001167867,0.0001249225,0.000046143,0.0001491058,0.0003539569,0.000004650407],"category_scores_gemma":[0.00005705357,0.0002104126,0.00007496904,0.0001719834,0.0001630492,0.00001037104,0.0001142999,0.0001953886,6.974783e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005128935,"about_ca_system_score_gemma":0.0001459248,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004167468,"about_ca_topic_score_gemma":0.0003551056,"domain_scores_codex":[0.9983822,0.0002985627,0.0003502356,0.0005450339,0.0001139658,0.0003100536],"domain_scores_gemma":[0.9993786,0.00005657205,0.0001148138,0.0002620771,0.0001088053,0.0000791687],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001600862,0.0001493659,0.1879241,0.00003366137,0.00008223375,0.00007170811,0.00008378396,0.00002899191,0.8105314,0.00001644934,0.0002229431,0.0006952657],"study_design_scores_gemma":[0.005386112,0.001071325,0.06207798,0.00006857797,0.0001292319,0.0001090827,0.0003486527,0.0003140493,0.9043438,0.000016737,0.02576067,0.0003738234],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997287,0.001206221,0.0001892442,0.0005829349,0.00018868,0.0004274192,0.00001870656,0.00001992665,0.0000799113],"genre_scores_gemma":[0.9986762,0.0001541191,0.0002026116,0.0007275144,0.00004551551,0.00004065055,0.00004035725,0.00002621167,0.00008679485],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1258461,"threshold_uncertainty_score":0.8580377,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01031928836619211,"score_gpt":0.2375107797627484,"score_spread":0.2271914913965563,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}