{"id":"W4416084925","doi":"10.1093/neuonc/noaf201.0166","title":"BIOM-78. DNA-METHYLATION PROFILING OF PAN-CANCER BRAIN METASTASES REVEALS EPIGENETIC SIGNATURE ASSOCIATED WITH IMPROVED PATIENT OUTCOMES","year":2025,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Brain Metastases and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; University of Toronto","funders":"","keywords":"Epigenetics; DNA methylation; Concordance; Gene expression profiling; Methylation; Genotyping; Survival analysis; Gene signature","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003544463,0.0002841046,0.0004195543,0.0005289302,0.0002038159,0.0004181608,0.0003139099,0.0002664354,0.00379764],"category_scores_gemma":[0.0007354813,0.0001529305,0.0002259444,0.0006482818,0.0001226326,0.0001385897,0.0004412041,0.0003818612,0.0009924888],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00028488,"about_ca_system_score_gemma":0.0002902184,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001680224,"about_ca_topic_score_gemma":0.003077149,"domain_scores_codex":[0.999721,0.00003858842,0.00002001784,0.0001113869,0.00006912011,0.0000398211],"domain_scores_gemma":[0.9996184,0.00006845494,0.0001196852,0.00004561996,0.00008156748,0.00006628822],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004846918,0.0003625057,0.4880228,0.0005807206,0.000574321,0.0002844415,0.0002323756,0.003336343,0.3988432,0.0003607979,0.007040098,0.09551542],"study_design_scores_gemma":[0.0001334724,0.0008859781,0.8753979,0.00003935632,0.0003112944,0.001083968,0.0001447291,0.01349073,0.09934181,0.0006097078,0.008515767,0.00004531216],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.982284,0.0006688852,0.002200628,0.0001124204,0.00001356802,0.0000359006,0.01317497,0.0001834061,0.00132622],"genre_scores_gemma":[0.9780195,0.0002551845,0.002675822,0.00006298016,0.00001179178,0.00006983658,0.01771264,0.00003733224,0.001154984],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00379764,"threshold_uncertainty_score":0.01270443,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01815854768656045,"score_gpt":0.3201816272214394,"score_spread":0.302023079534879,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}