{"id":"W4416084933","doi":"10.1093/neuonc/noaf201.0463","title":"CTIM-06. NIACIN MODULATES IMMUNE RESPONSES IN A PHASE I DOSE-ESCALATION CLINICAL TRIAL OF NEWLY DIAGNOSED GLIOBLASTOMA","year":2025,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Immune cells in cancer","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; University of Calgary","funders":"","keywords":"Niacin; Immune system; Clinical trial; Cytokine; Immunosuppression; Immunotherapy; Leukapheresis; Immunosenescence; Myeloid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009785752,0.0009704336,0.001410357,0.0004103015,0.0002781998,0.0007421806,0.0007814603,0.0007920653,0.002502325],"category_scores_gemma":[0.0004969598,0.0003730146,0.000696464,0.0003508021,0.000628238,0.0004607703,0.0002869774,0.002379064,0.0005097609],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000664283,"about_ca_system_score_gemma":0.001207645,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00101167,"about_ca_topic_score_gemma":0.003111134,"domain_scores_codex":[0.9996846,0.0001569715,0.00001841834,0.00004048662,0.00002541,0.00007417717],"domain_scores_gemma":[0.9996489,0.00004509802,0.000075926,0.00002934293,0.00002886097,0.000171871],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.6772942,0.09218843,0.005336135,0.001127708,0.001050909,0.0001925255,0.0002898575,0.002627022,0.07679684,0.0003336147,0.003689745,0.1390731],"study_design_scores_gemma":[0.3637887,0.6143421,0.008464682,0.0000517773,0.0003590025,0.0001565312,0.00007099737,0.001418083,0.009367553,0.0001383449,0.001812741,0.00002955107],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960532,0.001218455,0.0002025245,0.0002195962,0.00008340021,0.001021717,0.0003211884,0.00005525944,0.0008246155],"genre_scores_gemma":[0.9943689,0.001014873,0.0007589855,0.0003171295,0.00007306808,0.001165042,0.0006580856,0.00001100525,0.001632999],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002502325,"threshold_uncertainty_score":0.008371115,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02979607474415171,"score_gpt":0.3701827246806268,"score_spread":0.3403866499364751,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}