{"id":"W4416084970","doi":"10.1093/neuonc/noaf201.0591","title":"CTP-19. Molecular characterization of the SJMB12 clinical trial for children and young adults with newly diagnosed medulloblastoma","year":2025,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Centre Hospitalier Universitaire Sainte-Justine; Alberta Children's Hospital","funders":"","keywords":"Germline; PTCH1; Medulloblastoma; Germline mutation; Exome sequencing; Exon; Gene; Clinical trial; Exome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001396673,0.0003611314,0.0008620769,0.0004968058,0.00024507,0.0008095256,0.0003904931,0.000460133,0.003911378],"category_scores_gemma":[0.001626192,0.0002293717,0.0006007903,0.0007594458,0.0003031734,0.0003362454,0.0002576121,0.0008719945,0.0006822769],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008200883,"about_ca_system_score_gemma":0.00135649,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002329488,"about_ca_topic_score_gemma":0.01062635,"domain_scores_codex":[0.9994616,0.0002159609,0.00005049629,0.00008447766,0.00009938232,0.00008809279],"domain_scores_gemma":[0.9992756,0.0001252816,0.0002577513,0.00003997996,0.00006138125,0.0002400037],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.3293275,0.003177587,0.2613868,0.00273494,0.002542706,0.0008228695,0.00043348,0.002872828,0.05770307,0.002322566,0.0204917,0.316184],"study_design_scores_gemma":[0.1133299,0.08050738,0.7229577,0.0004913955,0.002716122,0.002076047,0.0002838185,0.003921767,0.0112187,0.002011191,0.06038617,0.00009972941],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9723292,0.0095865,0.000595914,0.001172078,0.0001338052,0.001146917,0.009323914,0.00009085083,0.005620863],"genre_scores_gemma":[0.9805414,0.002573188,0.001765975,0.0008347208,0.0001181313,0.001923274,0.009682174,0.00004438632,0.00251677],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003911378,"threshold_uncertainty_score":0.01308483,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01346328353725241,"score_gpt":0.3111997749173576,"score_spread":0.2977364913801052,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}